Literature summary extracted from

Radeff-Huang, J.; Seasholtz, T.M.; Chang, J.W.; Smith, J.M.; Walsh, C.T.; Brown, J.H.
Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression (2007), J. Biol. Chem., 282, 863-870.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.1.91	tumor necrosis factor-alpha	100 ng/ml	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.91	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.91	glioblastoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.91	ATP + sphingosine	-	Homo sapiens	ADP + sphingosine 1-phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.1.91	sphinganine kinase	-	Homo sapiens
2.7.1.91	SPHK	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.7.1.91	ATP	-	Homo sapiens

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Release 2023.1 (January 2023)