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Literature summary extracted from

  • Shindou, H.; Hishikawa, D.; Nakanishi, H.; Harayama, T.; Ishii, S.; Taguchi, R.; Shimizu, T.
    A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells: cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase (2007), J. Biol. Chem., 282, 6532-6539.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.67
-
 Mus musculus
2.3.1.67
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.67 microsome microsomal protein with three putative membrane-spanning domains Mus musculus
-
-
2.3.1.67 microsome microsomal protein with three putative membrane-spanning domains Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.67 additional information Mus musculus enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF ?
-
 ?
2.3.1.67 additional information Homo sapiens enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Homo sapiens Q7L5N7
-
-
2.3.1.67 Mus musculus Q8BYI6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor
-
 Mus musculus platelet-activating factor + CoA
-
 ?
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor
-
 Homo sapiens platelet-activating factor + CoA
-
 ?
2.3.1.67 additional information enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF Mus musculus ?
-
 ?
2.3.1.67 additional information enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.67 acetyl-CoA:lyso-PAF acetyltransferase
-
 Mus musculus
2.3.1.67 acetyl-CoA:lyso-PAF acetyltransferase
-
 Homo sapiens
2.3.1.67 lpafat1
-
 Homo sapiens
2.3.1.67 lyso-PAF acetyltransferase:LPC acyltransferase 1
-
 Mus musculus
2.3.1.67 lyso-PAF acetyltransferase:LPC acyltransferase 1
-
 Homo sapiens
2.3.1.67 mLysoPAFAT/LPCAT2
-
 Mus musculus