EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.1.134 | sitting drop vapor diffusion method | Homo sapiens |
2.7.1.159 | - |
Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.1.134 | H162D | loss-of-function for Ins(1,3,4)P3 in the H162D mutant is matched by a 200fold reduction in its Ins(1,3,4)P3 kinase activity. The H162D mutant dephosphorylats Ins(1,3,4,5,6)P5 almost twice as fast as the wild-type enzyme. The H162D mutant also displays very limited ability to transfer phosphate from Ins(1,3,4,5,6)P5 to Ins(1,3,4)P3 in the presence of physiological concentrations of nucleotide | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.134 | additional information | Homo sapiens | phosphate is transferred between inositol phosphates via ITPK1-bound nucleotide. Intersubstrate phosphate transfer explains how competing substrates are able to stimulate each others catalysis by ITPK1 | ? | - |
? | |
2.7.1.159 | additional information | Homo sapiens | integration of inositol phosphate signaling pathways via human ITPK1 | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.134 | Homo sapiens | - |
- |
- |
2.7.1.159 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.134 | ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate | - |
? | |
2.7.1.134 | ATP + D-myo-inositol 1,3,4-triphosphate | - |
Homo sapiens | ? | - |
? | |
2.7.1.134 | additional information | phosphate is transferred between inositol phosphates via ITPK1-bound nucleotide. Intersubstrate phosphate transfer explains how competing substrates are able to stimulate each others catalysis by ITPK1 | Homo sapiens | ? | - |
? | |
2.7.1.159 | additional information | integration of inositol phosphate signaling pathways via human ITPK1 | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.134 | ITPK1 | - |
Homo sapiens |
2.7.1.159 | inositol 1,3,4-trisphosphate 5/6-kinase | - |
Homo sapiens |
2.7.1.159 | ITPK1 | - |
Homo sapiens |