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Literature summary extracted from

  • Chamberlain, P.P.; Qian, X.; Stiles, A.R.; Cho, J.; Jones, D.H.; Lesley, S.A.; Grabau, E.A.; Shears, S.B.; Spraggon, G.
    Integration of inositol phosphate signaling pathways via human ITPK1 (2007), J. Biol. Chem., 282, 28117-28125.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.134 sitting drop vapor diffusion method Homo sapiens
2.7.1.159
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.134 H162D loss-of-function for Ins(1,3,4)P3 in the H162D mutant is matched by a 200fold reduction in its Ins(1,3,4)P3 kinase activity. The H162D mutant dephosphorylats Ins(1,3,4,5,6)P5 almost twice as fast as the wild-type enzyme. The H162D mutant also displays very limited ability to transfer phosphate from Ins(1,3,4,5,6)P5 to Ins(1,3,4)P3 in the presence of physiological concentrations of nucleotide Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.134 additional information Homo sapiens phosphate is transferred between inositol phosphates via ITPK1-bound nucleotide. Intersubstrate phosphate transfer explains how competing substrates are able to stimulate each others’ catalysis by ITPK1 ?
-
 ?
2.7.1.159 additional information Homo sapiens integration of inositol phosphate signaling pathways via human ITPK1 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.134 Homo sapiens
-
-
-
2.7.1.159 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.134 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
-
 ?
2.7.1.134 ATP + D-myo-inositol 1,3,4-triphosphate
-
 Homo sapiens ?
-
 ?
2.7.1.134 additional information phosphate is transferred between inositol phosphates via ITPK1-bound nucleotide. Intersubstrate phosphate transfer explains how competing substrates are able to stimulate each others’ catalysis by ITPK1 Homo sapiens ?
-
 ?
2.7.1.159 additional information integration of inositol phosphate signaling pathways via human ITPK1 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.134 ITPK1
-
 Homo sapiens
2.7.1.159 inositol 1,3,4-trisphosphate 5/6-kinase
-
 Homo sapiens
2.7.1.159 ITPK1
-
 Homo sapiens