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Literature summary extracted from

  • Ku, S.Y.; Yip, P.; Cornell, K.A.; Behr, J.B.; Guillerm, G.; Howell, P.L.
    Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding (2007), J. Biol. Chem., 282, 22195-22206.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.100 medicine 5-methylthioribose kinase is a key enzyme in methionine salvage in bacteria and the absence of a mammalian homolog suggests that it is a good target for the design of novel antibiotics Bacillus subtilis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.100 structure determination of apo-MTR kinase and its substrate complexes with ADP, ADP-PO4 and beta,gamma-methyleneadenosine 5'-triphosphate Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.100 ATP + S-methyl-5-thio-D-ribose Bacillus subtilis 5-methylthioribose kinase is a key enzyme in methionine salvage in bacteria ADP + S-methyl-5-thio-D-ribose 1-phosphate
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Organism

EC Number Organism UniProt Comment Textmining
2.7.1.100 Bacillus subtilis
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.100 ATP + S-methyl-5-thio-D-ribose 5-methylthioribose kinase is a key enzyme in methionine salvage in bacteria Bacillus subtilis ADP + S-methyl-5-thio-D-ribose 1-phosphate
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?
2.7.1.100 ATP + S-methyl-5-thio-D-ribose dissociative mechanism Bacillus subtilis ADP + S-methyl-5-thio-D-ribose 1-phosphate
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?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.100 5-methylthioribose kinase
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Bacillus subtilis
2.7.1.100 MTR kinase
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Bacillus subtilis
2.7.1.100 MTRK
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Bacillus subtilis