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Literature summary extracted from

  • Manya, H.; Suzuki, T.; Akasaka-Manya, K.; Ishida, H.K.; Mizuno, M.; Suzuki, Y.; Inazu, T.; Dohmae, N.; Endo, T.
    Regulation of mammalian protein O-mannosylation: Preferential amino acid sequence for O-mannose modification (2007), J. Biol. Chem., 282, 20200-20206.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.109 0.63
-
 synthetic peptide based on a mucin-like domain in alpha-dystroglycan 25°C, pH 8.0 Homo sapiens
2.4.1.109 0.73
-
 synthetic peptide based on a mucin-like domain in alpha-dystroglycan 25°C, pH 8.0 Homo sapiens
2.4.1.109 2.96
-
 synthetic peptide based on a mucin-like domain in alpha-dystroglycan 25°C, pH 8.0 Homo sapiens
2.4.1.109 2.98
-
 synthetic peptide based on a mucin-like domain in alpha-dystroglycan 25°C, pH 8.0 Homo sapiens
2.4.1.109 9.7
-
 synthetic peptide based on a mucin-like domain in alpha-dystroglycan 25°C, pH 8.0 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.109 dolichyl phosphate D-mannose + protein Homo sapiens catalyzes the initial step of O-mannosyl glycan biosynthesis dolichyl phosphate + O-D-mannosylprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.109 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.109 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.109 dolichyl beta-D-mannosyl phosphate + synthetic peptide based on a mucin-like domain in alpha-dystroglycan
-
 Homo sapiens ?
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein catalyzes the initial step of O-mannosyl glycan biosynthesis Homo sapiens dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein synthetic peptides based on a mucin-like domain in alpha-dystroglycan. Thr414 of peptide 401-420 and Thr351 of peptide 336-355 are prominently modified by O-mannosylation Homo sapiens dolichyl phosphate + O-D-mannosylprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.109 POMT1
-
 Homo sapiens
2.4.1.109 POMT2
-
 Homo sapiens
2.4.1.109 protein O-mannosyltransferase
-
 Homo sapiens