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Literature summary extracted from

  • Yoshizawa, J.M.; Li, C.; Gershon, P.D.
    Saltatory forward movement of a poly(A) polymerase during poly(A) tail addition (2007), J. Biol. Chem., 282, 19144-19151.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.19 Vaccinia virus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.19
-
 Vaccinia virus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.7.19 ATP + RNAn = diphosphate + RNAn+3'-A non-uniform isomerization of the polymerase-primer complex with time consistent with a discontinuous (saltatory) translocation mechanism. Three distinct translocatory phases can be discerned: a -10(U)-binding site forward movement, a -27/-26(UU)-binding site jump to -10, then a -27/-26(UU)-binding site movement further downstream. Poly(A) tail elongation shows no apparent pauses during these isomerizations Vaccinia virus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.19 ATP + RNA
-
 Vaccinia virus diphosphate + RNA(A)n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.19 PAP
-
 Vaccinia virus
2.7.7.19 poly(A) polymerase
-
 Vaccinia virus
2.7.7.19 VP55
-
 Vaccinia virus