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Literature summary extracted from

  • Liu, J.; Timm, D.E.; Hurley, T.D.
    Pyrithiamine as a substrate for thiamine pyrophosphokinase (2006), J. Biol. Chem., 281, 6601-6607.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.6.2 additional information Administration of oxythiamine to animals produces primarily metabolic aberrations such as lethargy and anorexia while the administration of pyrithiamine to animals produces neurological problems similar to Wernicke-Korsakoff Syndrome. Mus musculus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.6.2 Crystallization experiments were set up by incubating mouse TPK with pyrithiamine and MgATP2- prior to adding the equilibrium mixture of enzyme, substrate, and products to the previously determined crystallization conditions. Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.6.2 pyrithiamine
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.6.2 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.2 thiamine + ATP Mus musculus
-
 thiamine diphosphate + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.2 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.2 oxythiamine + ATP
-
 Mus musculus oxythiamine diphosphate + AMP
-
 ?
2.7.6.2 pyrithiamine + ATP inhibits the substrate thiamine Mus musculus pyrithiamine diphosphate + AMP
-
 ?
2.7.6.2 thiamine + ATP
-
 Mus musculus thiamine diphosphate + AMP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.6.2 homodimer
-
 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.6.2 thiamine pyrophosphokinase
-
 Mus musculus