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Literature summary extracted from

  • Field, M.S.; Szebenyi, D.M.; Stover, P.J.
    Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma (2006), J. Biol. Chem., 281, 4215-4221.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.3.2 10-formylfolic acid
-
 Homo sapiens
6.3.3.2 folic acid
-
 Homo sapiens
6.3.3.2 folic acid pentaglutamate
-
 Homo sapiens
6.3.3.2 folic acid triglutamate
-
 Homo sapiens
6.3.3.2 [6R,S]-10-formyltetrahydrofolate triglutamate
-
 Homo sapiens
6.3.3.2 [6R,S]-10-formyltetrahydrohomofolate
-
 Homo sapiens
6.3.3.2 [6R,S]-10-formyltetrahydropteroate
-
 Homo sapiens
6.3.3.2 [6R,S]-5-formyltetrahydrohomofolate
-
 Homo sapiens
6.3.3.2 [6R]-10-formyltetrahydrofolate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.3.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.3.2 neuroblastoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
 Homo sapiens ADP + 5,10-methenyltetrahydrofolate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.3.2 Methenyltetrahydrofolate synthetase
-
 Homo sapiens
6.3.3.2 MTHFS
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.3.2 0.00003
-
 [6R,S]-10-formyltetrahydrofolate triglutamate at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.0001
-
 folic acid pentaglutamate at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.00015
-
 [6R]-10-formyltetrahydrofolate at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.0002
-
 [6R,S]-10-formyltetrahydrohomofolate at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.0007
-
 [6R,S]-5-formyltetrahydrohomofolate at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.0017
-
 folic acid triglutamate at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.005
-
 [6R,S]-10-formyltetrahydropteroate at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.013
-
 10-formylfolic acid at 37°C in 100 mM MES, pH 6.0 Homo sapiens
6.3.3.2 0.058
-
 folic acid at 37°C in 100 mM MES, pH 6.0 Homo sapiens