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Literature summary extracted from

  • Tanos, B.; Pendergast, A.M.
    Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor (2006), J. Biol. Chem., 281, 32714-32723.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 epidermal growth factor receptor the Abl nonreceptor tyrosine kinase is activated by ligand-stimulated EGFR Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.2 co-expression of EGFR and Abl in COS-7 cell surface, expression in HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 K290M a kinase-inactive Abl mutant Homo sapiens
2.7.10.2 additional information Abl-PP harbors mutations in prolines 242 and 249 in theSH2kinase linker domain, which are mutated to glutamic acid, rendering Abl in a constitutively active state Homo sapiens
2.7.10.2 P131L a SH3-domain mutant with increased activity compared to wild-type Abl Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 AbI kinase activated Abl kinase phosphorylates the EGFR at specific sites and uncouples the receptor from ligand-mediated internalization Homo sapiens
2.7.10.1 dynamin K44A reduces EGFR internalization to 40% Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + epidermal growth factor receptor Homo sapiens the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-
2.7.10.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + epidermal growth factor receptor the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability Homo sapiens ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
-
 ?
2.7.10.2 ATP + epidermal growth factor receptor activated Abl phosphorylates the EGFR primarily on Tyr1173, no activity with the Tyr1173 mutant substrate Homo sapiens ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 Egfr
-
 Homo sapiens
2.7.10.1 epidermal growth factor receptor
-
 Homo sapiens
2.7.10.2 Abl
-
 Homo sapiens
2.7.10.2 Abl nonreceptor tyrosine kinase
-
 Homo sapiens
2.7.10.2 Abl tyrosine kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 Homo sapiens
2.7.10.2 ATP
-
 Homo sapiens