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Literature summary extracted from

  • Klinman, J.P.
    The copper-enzyme family of dopamine b-monooxygenase and peptidylglycine a-hydroxylating monooxygenase: Resolving the chemical pathway for substrate hydroxylation (2006), J. Biol. Chem., 281, 3013-3016.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.17.1 Cu2+ The enzyme contains two copper centers, one performs the substrate hydroxylation, while the second is used for electron storage/transfer Homo sapiens
1.14.17.3 Cu2+ The enzyme contains two copper centers, one performs the substrate hydroxylation, while the second is used for electron storage/transfer Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 Homo sapiens
-
 noradrenaline + dehydroascorbate + H2O
-
 ?
1.14.17.3 peptidylglycine + ascorbate + O2 Homo sapiens
-
 peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Homo sapiens
-
-
-
1.14.17.3 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Homo sapiens noradrenaline + dehydroascorbate + H2O
-
 ?
1.14.17.3 peptidylglycine + ascorbate + O2
-
 Homo sapiens peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DbetaM
-
 Homo sapiens
1.14.17.1 dopamine beta-monooxygenase
-
 Homo sapiens
1.14.17.3 peptidylglycine alpha-hydroxylating-monooxygenase
-
 Homo sapiens
1.14.17.3 PHM
-
 Homo sapiens