EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.2.1 | expression in Escherichia coli | Toxoplasma gondii |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.1 | 5'-methylthio-immucillin-H | - |
Plasmodium falciparum | |
2.4.2.1 | deoxyimmucillin-H | - |
Plasmodium falciparum | |
2.4.2.1 | deoxyimmucillin-H | - |
Toxoplasma gondii | |
2.4.2.1 | immucillin-G | - |
Plasmodium falciparum | |
2.4.2.1 | immucillin-G | - |
Toxoplasma gondii | |
2.4.2.1 | immucillin-H | - |
Plasmodium falciparum | |
2.4.2.1 | immucillin-H | - |
Toxoplasma gondii | |
2.4.2.1 | additional information | insensitive to methylthio-immucillin-H | Toxoplasma gondii |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.1 | 0.0047 | - |
Inosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 0.0094 | - |
guanosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 0.0094 | - |
guanosine | pH 7.4 | Toxoplasma gondii | |
2.4.2.1 | 0.0106 | - |
5'-methylthioadenosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 0.0131 | - |
Inosine | pH 7.4 | Toxoplasma gondii | |
2.4.2.1 | 0.0319 | - |
5'-methylthioadenosine | pH 7.4 | Toxoplasma gondii | |
2.4.2.1 | 0.091 | - |
deoxyinosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 0.115 | - |
uridine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 0.259 | - |
deoxyinosine | pH 7.4 | Toxoplasma gondii |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.1 | Plasmodium falciparum | Q8T9Z7 | - |
- |
2.4.2.1 | Toxoplasma gondii | Q2HXR2 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.2.1 | recombinant | Toxoplasma gondii |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.2.1 | tachyzoite | - |
Toxoplasma gondii | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.1 | 5'-methylthioadenosine + phosphate | - |
Plasmodium falciparum | adenine + 5-methylthio-alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | 5'-methylthioadenosine + phosphate | - |
Toxoplasma gondii | adenine + 5-methylthio-alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | 5'-methylthioinosine + phosphate | very low activity | Toxoplasma gondii | hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | 5'-methylthioinosine + phosphate | ver low activity | Plasmodium falciparum | hypoxanthine + 5-methylthio-alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | deoxyinosine + phosphate | - |
Plasmodium falciparum | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
? | |
2.4.2.1 | deoxyinosine + phosphate | - |
Toxoplasma gondii | hypoxanthine + alpha-D-deoxyribose 1-phosphate | - |
? | |
2.4.2.1 | guanosine + phosphate | - |
Plasmodium falciparum | guanine + alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | guanosine + phosphate | - |
Toxoplasma gondii | guanine + alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | inosine + phosphate | - |
Plasmodium falciparum | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | inosine + phosphate | - |
Toxoplasma gondii | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
2.4.2.1 | uridine + phosphate | - |
Plasmodium falciparum | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.2.1 | PfPNP | - |
Plasmodium falciparum |
2.4.2.1 | TgPNP | - |
Toxoplasma gondii |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.1 | 0.027 | - |
5'-methylthioadenosine | pH 7.4 | Toxoplasma gondii | |
2.4.2.1 | 0.09 | - |
uridine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 0.48 | - |
deoxyinosine | pH 7.4 | Toxoplasma gondii | |
2.4.2.1 | 0.89 | - |
deoxyinosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 1.1 | - |
Inosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 2.6 | - |
Inosine | pH 7.4 | Toxoplasma gondii | |
2.4.2.1 | 2.6 | - |
guanosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 2.6 | - |
5'-methylthioadenosine | pH 7.4 | Plasmodium falciparum | |
2.4.2.1 | 3.6 | - |
guanosine | pH 7.4 | Toxoplasma gondii |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.1 | 0.0000006 | - |
immucillin-H | pH 7.4, equilibrium inhibition constant | Plasmodium falciparum | |
2.4.2.1 | 0.0000009 | - |
immucillin-G | pH 7.4, equilibrium inhibition constant | Plasmodium falciparum | |
2.4.2.1 | 0.00000189 | - |
immucillin-G | pH 7.4, equilibrium inhibition constant | Toxoplasma gondii | |
2.4.2.1 | 0.00000203 | - |
immucillin-H | pH 7.4, equilibrium inhibition constant | Toxoplasma gondii | |
2.4.2.1 | 0.0000027 | - |
5'-methylthio-immucillin-H | pH 7.4, equilibrium inhibition constant | Plasmodium falciparum | |
2.4.2.1 | 0.0000074 | - |
deoxyimmucillin-H | pH 7.4, equilibrium inhibition constant | Plasmodium falciparum | |
2.4.2.1 | 0.00001 | - |
deoxyimmucillin-H | pH 7.4, equilibrium inhibition constant | Toxoplasma gondii | |
2.4.2.1 | 0.000029 | - |
immucillin-H | pH 7.4, inhibition constant during slow-onset phase | Plasmodium falciparum | |
2.4.2.1 | 0.00013 | - |
deoxyimmucillin-H | pH 7.4, inhibition constant during slow-onset phase | Plasmodium falciparum | |
2.4.2.1 | 0.000346 | - |
immucillin-G | pH 7.4, inhibition constant during slow-onset phase | Toxoplasma gondii | |
2.4.2.1 | 0.00045 | - |
immucillin-H | pH 7.4, inhibition constant during slow-onset phase | Toxoplasma gondii | |
2.4.2.1 | 0.000682 | - |
deoxyimmucillin-H | pH 7.4, inhibition constant during slow-onset phase | Toxoplasma gondii |