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Literature summary extracted from

  • Pandhare, J.; Cooper, S.K.; Phang, J.M.
    Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms (2006), J. Biol. Chem., 281, 2044-2052.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.5.1.2 P53 POX is a p53-induced gene Homo sapiens
1.5.1.2 troglitazone is found to activate the POX promoter in colon cancer cells Homo sapiens

Application

EC Number Application Comment Organism
1.5.1.2 medicine proline oxidase can mediate apoptosis through generation of reactive oxygen species Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.2 a proline oxidase antisense vector is constructed by amplifying a part of the proline oxidase cDNA and cloning it in the mammalian expression vector pCI Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.2 mitochondrial inner membrane
-
 Homo sapiens 5743
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.2 L-proline + NAD(P)+ Homo sapiens
-
 1-pyrroline-5-carboxylate + NAD(P)H + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.2 HCC-2998 cell
-
 Homo sapiens
-
1.5.1.2 HCT-116 cell
-
 Homo sapiens
-
1.5.1.2 HCT-15 cell
-
 Homo sapiens
-
1.5.1.2 HEK-293 cell
-
 Homo sapiens
-
1.5.1.2 HT-29 cell
-
 Homo sapiens
-
1.5.1.2 KM-12 cell
-
 Homo sapiens
-
1.5.1.2 LoVo cell
-
 Homo sapiens
-
1.5.1.2 RKO cell
-
 Homo sapiens
-
1.5.1.2 SW-620 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.2 L-proline + NAD(P)+
-
 Homo sapiens 1-pyrroline-5-carboxylate + NAD(P)H + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.5.1.2 POX
-
 Homo sapiens
1.5.1.2 proline oxidase
-
 Homo sapiens
1.5.1.2 pyrroline-5-carboxylate reductase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.2 37
-
 activity assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.2 7.2
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.2 NAD(P)H
-
 Homo sapiens