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Literature summary extracted from

  • Paone, G.; Stevens, L.A.; Levine, R.L.; Bourgeois, C.; Steagall, W.K.; Gochuico, B.R.; Moss, J.
    ADP-ribosyltransferase-specific modification of human neutrophil peptide-1 (2006), J. Biol. Chem., 281, 17054-17060.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.31 expression of isozymes ART1, ART3, ART4, ART5, ART2.2 in Escherichia coli, isozyme ART1synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modifiy arginine 14 on HNP-1 with a secondary site on arginine 24 Homo sapiens
2.4.2.31 expression of isozymes ART1, ART5, ART2.2 in Escherichia coli, ART1 expressed endogenously on C2C12 myotubes modifies arginine 14 on HNP-1 with a secondary site on arginine 24 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.31 human neutrophil peptide-1 substrate inhibition of isozymes ART1 and ART5 Homo sapiens
2.4.2.31 human neutrophil peptide-1 substrate inhibition of isozyme ART5 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.31 cell surface on epithelial cells lining human airways and cells, isozyme ART1 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.31 human neutrophil peptide-1 + NAD+ Homo sapiens human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.31 Homo sapiens
-
 isozymes ART1, ART3, ART4, and ART5
-
2.4.2.31 Mus musculus
-
 isozymes ART1, ART2.2, and ART5
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.31 epithelial cell epithelial cells lining human airways and cells, isozyme ART1, bronchoalveolar lavage fluid Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.31 human neutrophil peptide-1 + NAD+ human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis Homo sapiens Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
 ?
2.4.2.31 human neutrophil peptide-1 + NAD+ human neutrophil peptide-1, HNP-1, from neutrophil cell surface, isozyme ART1 is active on Arg14 and Arg24 Mus musculus Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
 ?
2.4.2.31 human neutrophil peptide-1 + NAD+ human neutrophil peptide-1, HNP-1, from neutrophil cell surface, isozyme ART1 shows high activity on Arg14 and Arg24, while isozymes ART3, ART4, ART5 are less or not active Homo sapiens Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
-
 ?
2.4.2.31 additional information substrate specificity, beta-defensin-1 is a poor substrate, overview Homo sapiens ?
-
 ?
2.4.2.31 additional information substrate specificity, human neutrophil peptide-1 is a poor substrate of isozymes ART2.2 and ART5, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.31 ADP-ribosyltransferase
-
 Mus musculus
2.4.2.31 ADP-ribosyltransferase
-
 Homo sapiens
2.4.2.31 arginine-specific ADP-ribosyltransferase
-
 Mus musculus
2.4.2.31 arginine-specific ADP-ribosyltransferase
-
 Homo sapiens
2.4.2.31 ART
-
 Mus musculus
2.4.2.31 ART
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.31 30
-
 assay at Mus musculus
2.4.2.31 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.31 7.5
-
 assay at Mus musculus
2.4.2.31 7.5
-
 assay at Homo sapiens