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Literature summary extracted from

  • Gale, S.E.; Frolov, A.; Han, X.; Bickel, P.E.; Cao, L.; Bowcock, A.; Schaffer, J.E.; Ory, D.S.
    A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation (2006), J. Biol. Chem., 281, 11082-11089.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.51 gene AGPAT2, expression of C-terminally HA-tagged AGPAT2 in CHO-K1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.51 additional information small interference RNA-mediated knockdown of AGPAT2 expression in OP-9 cells prevents appropriate early induction of C/EBPbeta and PPARgamma, key transcriptional activators of the adipogenic program, and delays expression of multiple adipocyte-related genes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.51 endoplasmic reticulum AGPAT2 is an integral membrane protein Homo sapiens 5783
-
2.3.1.51 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate Homo sapiens AGPAT2 catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor for both triacylglycerol and phospholipid synthesis, isozyme AGPAT2 plays a regulatory role in adipocyte differentiation CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Homo sapiens O15120 AGPAT2; gene AGPAT2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.51 recombinant enzyme partially from CHO-K1 cell microsomes Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.51 adipocyte isozyme AGPAT2 Homo sapiens
-
2.3.1.51 OP-9 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate AGPAT2 catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor for both triacylglycerol and phospholipid synthesis, isozyme AGPAT2 plays a regulatory role in adipocyte differentiation Homo sapiens CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.51 1-acylglycerol-3-phosphate-O-acyltransferase
-
 Homo sapiens
2.3.1.51 AGPAT
-
 Homo sapiens