Literature summary extracted from
Feng, J.; Che, Y.; Milse, J.; Yin, Y.J.; Liu, L.; Rueckert, C.; Shen, X.H.; Qi, S.W.; Kalinowski, J.; Liu, S.J.
The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum (2006), J. Biol. Chem., 281, 10778-10785.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
5.2.1.4 |
EDTA |
weak activator at 1 mM |
Corynebacterium glutamicum |
|
Application
EC Number |
Application |
Comment |
Organism |
---|
5.2.1.4 |
medicine |
mycothiol as target for clinical treatment |
Corynebacterium glutamicum |
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
5.2.1.4 |
expression in Escherichia coli |
Corynebacterium glutamicum |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
5.2.1.4 |
EDTA |
complete inhibitory at 10 mM |
Corynebacterium glutamicum |
|
5.2.1.4 |
Fe3+ |
weak inhibitor |
Corynebacterium glutamicum |
|
KM Value [mM]
EC Number |
KM Value [mM] |
KM Value Maximum [mM] |
Substrate |
Comment |
Organism |
Structure |
---|
5.2.1.4 |
148.4 |
- |
3-maleylpyruvate |
- |
Corynebacterium glutamicum |
|
Metals/Ions
EC Number |
Metals/Ions |
Comment |
Organism |
Structure |
---|
5.2.1.4 |
additional information |
Mg2+, Ca2+, Cu2+, Ni2+, Mn2+ have no effect |
Corynebacterium glutamicum |
|
5.2.1.4 |
Zn2+ |
activating |
Corynebacterium glutamicum |
|
Molecular Weight [Da]
EC Number |
Molecular Weight [Da] |
Molecular Weight Maximum [Da] |
Comment |
Organism |
---|
5.2.1.4 |
33000 |
- |
SDS-PAGE |
Corynebacterium glutamicum |
5.2.1.4 |
34000 |
- |
gel filtration |
Corynebacterium glutamicum |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
5.2.1.4 |
Corynebacterium glutamicum |
Q8NLC1 |
wild type; mshA-, mshB-, mshC-, mshD-deletion mutants |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
5.2.1.4 |
of the recombinant enzyme |
Corynebacterium glutamicum |
Storage Stability
EC Number |
Storage Stability |
Organism |
---|
5.2.1.4 |
at -80°C |
Corynebacterium glutamicum |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
5.2.1.4 |
3-maleylpyruvate + |
- |
Corynebacterium glutamicum |
3-fumarylpyruvate |
- |
? |
|
Subunits
EC Number |
Subunits |
Comment |
Organism |
---|
5.2.1.4 |
monomer |
1 x 33000, SDS-Page |
Corynebacterium glutamicum |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
5.2.1.4 |
3-maleylpyruvate cis-trans-isomerase |
- |
Corynebacterium glutamicum |
5.2.1.4 |
maleylpyruvate isomerase |
- |
Corynebacterium glutamicum |
5.2.1.4 |
MDMPI |
mycothiol dependent maleylpyruvate isomerase |
Corynebacterium glutamicum |
5.2.1.4 |
msh gene |
- |
Corynebacterium glutamicum |
5.2.1.4 |
ncgl2918 gene |
- |
Corynebacterium glutamicum |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
5.2.1.4 |
additional information |
MSH, mycothiol, 1D-myo-inosityl-1-(N-acetyl-L-cysteinyl)amido-2-deoxy-a-D-glucopyranoside, purified and identified by HPLC and mass spectrometric analysis |
Corynebacterium glutamicum |
|