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Literature summary extracted from

  • Meruvu Sunith, M.S.; Walther Matthia, W.M.; Ivanov Igo, I.I.; Hammarstrom Sve, H.S.; Furstenberger Gerhar, F.G.; Krieg Pete, K.P.; Reddanna Pall, R.P.; Kuhn Hartmu, K.H.
    Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis (2005), J. Biol. Chem., 280, 36633-36641.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.31 expressed in Escherichia coli and Sf9 insect cells Oryctolagus cuniculus

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.31 A455I 10% activity of the wild type enzyme Oryctolagus cuniculus
1.13.11.31 A455W 45% activity of the wild type enzyme Oryctolagus cuniculus
1.13.11.31 F390A 50% activity of the wild type enzyme Oryctolagus cuniculus
1.13.11.31 F390W 2% activity of the wild type enzyme Oryctolagus cuniculus
1.13.11.31 V631A 150% increase of activity of the wild type enzyme Oryctolagus cuniculus
1.13.11.31 V631F 4% activity of the wild type enzyme Oryctolagus cuniculus
1.13.11.31 V631G 173% increase of activity of the wild type enzyme Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Oryctolagus cuniculus
-
 rabbit
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 reticulocyte
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 20-hydroxyeicosatetraenoic acid methyl ester + O2
-
 Oryctolagus cuniculus 8,20-dihydroxyeicosatetraenoic acid + 12,20-dihydroxyeicosatetraenoic acid + 9,20-dihydroxyeicosatetraenoic acid
-
 ?
1.13.11.31 arachidonate + O2
-
 Oryctolagus cuniculus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 linoleic acid methyl ester + O2
-
 Oryctolagus cuniculus (9R)-hydroperoxy-(10E,12Z)-octadecadienoic acid methyl ester
-
 ?
1.13.11.31 methyl arachidonate + O2
-
 Oryctolagus cuniculus (15S,5Z,8Z,11Z,13E)-15-hydroxy-5,8,11,13-eicosatetraenoic acid methyl ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 (12R)-lipoxygenase
-
 Oryctolagus cuniculus
1.13.11.31 (12R)-LOX
-
 Oryctolagus cuniculus