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Literature summary extracted from

  • Scaglia, N.; Igal, R.A.
    Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells (2005), J. Biol. Chem., 280, 25339-25349.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.1 cDNA fragment corresponding to bp 278-2005 of the sequence was subcloned into a pcDNA3 vector in antisense orientation and stably transfected into SV40-WI38 lung fibroblasts cells, enzyme activity reduced in these stable cell clones, reduced protein level, reduced enzyme expression slows the rate of cell proliferation and suppresses anchorage-independent proliferation, SCD deficiency promotes apoptosis in a ceramide-independent manner Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens O00767
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 WI-38 cell SV40-transformed human lung fibroblasts, SV40-WI38 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearic acid + AH2 + O2
-
Homo sapiens oleic acid + A + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD
-
Homo sapiens