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Literature summary extracted from
- Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity (2005), J. Biol. Chem., 280, 25284-25290.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | trans,trans-curcumin | 0.01-0.05 mM, IC50: 0.0015 mM, irreversible inhibition | Homo sapiens |  |
| 1.8.1.9 | trans,trans-curcumin | IC50: 0.0036 mM, irreversible inhibition after incubation at room temperature for 2 h in vitro | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.9 | cytosol | TrxR1 | Homo sapiens | 5829 | - |
| 1.8.1.9 | cytosol | TrxR1 | Rattus norvegicus | 5829 | - |
| 1.8.1.9 | mitochondrion | TrxR2 | Homo sapiens | 5739 | - |
| 1.8.1.9 | mitochondrion | TrxR2 | Rattus norvegicus | 5739 | - |
| 1.8.1.9 | nucleus | TrxR1 | Homo sapiens | 5634 | - |
| 1.8.1.9 | nucleus | TrxR1 | Rattus norvegicus | 5634 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | Homo sapiens | - |
- |
- |
| 1.8.1.9 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | thioredoxin + NADP+ | - |
Homo sapiens | thioredoxin disulfide + NADPH | - |
? | |
| 1.8.1.9 | thioredoxin + NADP+ | - |
Rattus norvegicus | thioredoxin disulfide + NADPH | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | thioredoxin reductase | - |
Homo sapiens |
| 1.8.1.9 | thioredoxin reductase | - |
Rattus norvegicus |
| 1.8.1.9 | TrxR | - |
Homo sapiens |
| 1.8.1.9 | TrxR | - |
Rattus norvegicus |
| 1.8.1.9 | TrxR1 | - |
Homo sapiens |
| 1.8.1.9 | TrxR1 | - |
Rattus norvegicus |
| 1.8.1.9 | TrxR2 | - |
Homo sapiens |
| 1.8.1.9 | TrxR2 | - |
Rattus norvegicus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.9 | 0.0015 | - |
0.01-0.05 mM, IC50: 0.0015 mM, irreversible inhibition | Homo sapiens | trans,trans-curcumin | |
| 1.8.1.9 | 0.0036 | - |
IC50: 0.0036 mM, irreversible inhibition after incubation at room temperature for 2 h in vitro | Rattus norvegicus | trans,trans-curcumin | |
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Release 2023.1 (January 2023)
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