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Literature summary extracted from

  • Piantedosi, R.; Ghyselinck, N.; Blaner, W.S.; Vogel, S.
    Cellular retinol-binding protein type III is needed for retinoid incorporation into milk (2005), J. Biol. Chem., 280, 24286-24292.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.135 cellular retinol-binding protein CRBP, required for enzyme activity, CRBP-I and CRBP-III each compensate for the absence of the other, specifically in mammary tissue, adipose tissue, muscle, and heart Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.135 additional information disruption of the CRBP-III gene and generation of CRBPIII-/- mice, method, overview, [cellular retinol-binding protein III]-deficient female mice produce milk with less retinyl ester content, especially retinyl-palmitate, compared to wild-type mice, the expression of CRBP-I is increased in adipose tissue of CRBP-III-/- mice compared to the wild-type mice Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.135 apo-CRBP-I i.e. apo-[cellular retinol-binding protein I], no inhibition by apo-CRBP-III Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 lecithin + retinol-[cellular retinol-binding protein III] Mus musculus the enzyme is responsible for catalyzing retinyl ester formation from retinol 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
2.3.1.135 lecithin + retinol-[cellular retinol-binding protein III] Mus musculus C57/BL6J the enzyme is responsible for catalyzing retinyl ester formation from retinol 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Mus musculus
-
 C57BL/6J mice
-
2.3.1.135 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 adipose tissue
-
 Mus musculus
-
2.3.1.135 heart
-
 Mus musculus
-
2.3.1.135 mammary gland
-
 Mus musculus
-
2.3.1.135 muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 lecithin + retinol-[cellular retinol-binding protein III] the enzyme is responsible for catalyzing retinyl ester formation from retinol Mus musculus 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
2.3.1.135 lecithin + retinol-[cellular retinol-binding protein III] retinol bound to cellular retinol-binding protein III, CRBP-III, is an excellent substrate for lecithin-retinol acyltransferase Mus musculus 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
2.3.1.135 lecithin + retinol-[cellular retinol-binding protein III] the enzyme is responsible for catalyzing retinyl ester formation from retinol Mus musculus C57/BL6J 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
2.3.1.135 lecithin + retinol-[cellular retinol-binding protein III] retinol bound to cellular retinol-binding protein III, CRBP-III, is an excellent substrate for lecithin-retinol acyltransferase Mus musculus C57/BL6J 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin-retinol acyltransferase
-
 Mus musculus
2.3.1.135 LRAT
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.135 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.135 8.5
-
 assay at Mus musculus