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Literature summary extracted from
- Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors (2005), J. Biol. Chem., 280, 15761-15766.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.4.3.4 | sitting-drop vapor diffusion method, crystal structures of MAO B in complex with trans,trans-farnesol and that of the I199F MAO B mutant protein | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.4 | 1,4-diphenyl-2-butene | monoamine oxidase B | Equus caballus |  |
| 1.4.3.4 | 1,4-diphenyl-2-butene | monoamine oxidase B | Homo sapiens | |
| 1.4.3.4 | 1,4-diphenyl-2-butene | monoamine oxidase B | Rattus norvegicus | |
| 1.4.3.4 | 8-(3-chlorostyryl)caffeine | monoamine oxidase B | Equus caballus | |
| 1.4.3.4 | 8-(3-chlorostyryl)caffeine | monoamine oxidase B | Homo sapiens | |
| 1.4.3.4 | 8-(3-chlorostyryl)caffeine | monoamine oxidase B | Mus musculus | |
| 1.4.3.4 | 8-(3-chlorostyryl)caffeine | monoamine oxidase B | Rattus norvegicus | |
| 1.4.3.4 | isatin | - |
Bos taurus | |
| 1.4.3.4 | isatin | monoamine oxidase A; monoamine oxidase B | Homo sapiens | |
| 1.4.3.4 | additional information | no inhibition of monoamine oxidase B: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine or 1,4-diphenyl-2-butene | Bos taurus | |
| 1.4.3.4 | additional information | no inhibition of monoamine oxidase A: trans,trans-farnesol, 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene | Homo sapiens | |
| 1.4.3.4 | additional information | no inhibition of monoamine oxidase B: isatin, trans,trans-farnesol, 8-(3-chlorostyryl)caffeine or 1,4-diphenyl-2-butene | Ovis aries | |
| 1.4.3.4 | trans,trans-farnesol | monoamine oxidase B | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | Bos taurus | P56560 | - |
- |
| 1.4.3.4 | Equus caballus | - |
- |
- |
| 1.4.3.4 | Homo sapiens | P21397 | - |
- |
| 1.4.3.4 | Homo sapiens | P27338 | - |
- |
| 1.4.3.4 | Mus musculus | Q8BW75 | - |
- |
| 1.4.3.4 | Ovis aries | - |
- |
- |
| 1.4.3.4 | Rattus norvegicus | P19643 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.4.3.4 | liver | - |
Equus caballus | - |
| 1.4.3.4 | liver | - |
Rattus norvegicus | - |
| 1.4.3.4 | liver | - |
Mus musculus | - |
| 1.4.3.4 | liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.4 | benzylamine + H2O + O2 | monoamine oxidase B | Ovis aries | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | benzylamine + H2O + O2 | monoamine oxidase B | Equus caballus | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | benzylamine + H2O + O2 | monoamine oxidase B | Homo sapiens | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | benzylamine + H2O + O2 | monoamine oxidase B | Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | benzylamine + H2O + O2 | monoamine oxidase B | Mus musculus | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | benzylamine + H2O + O2 | monoamine oxidase B | Bos taurus | benzaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.4 | kynuramine + H2O + O2 | monoamine oxidase A | Homo sapiens | 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.4 | MAO A | - |
Homo sapiens |
| 1.4.3.4 | MAO B | - |
Ovis aries |
| 1.4.3.4 | MAO B | - |
Equus caballus |
| 1.4.3.4 | MAO B | - |
Homo sapiens |
| 1.4.3.4 | MAO B | - |
Rattus norvegicus |
| 1.4.3.4 | MAO B | - |
Mus musculus |
| 1.4.3.4 | MAO B | - |
Bos taurus |
| 1.4.3.4 | monoamine oxidase A | - |
Homo sapiens |
| 1.4.3.4 | monoamine oxidase B | - |
Ovis aries |
| 1.4.3.4 | monoamine oxidase B | - |
Equus caballus |
| 1.4.3.4 | monoamine oxidase B | - |
Homo sapiens |
| 1.4.3.4 | monoamine oxidase B | - |
Rattus norvegicus |
| 1.4.3.4 | monoamine oxidase B | - |
Mus musculus |
| 1.4.3.4 | monoamine oxidase B | - |
Bos taurus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.4 | 0.0002 | - |
8-(3-chlorostyryl)caffeine | monoamine oxidase B | Homo sapiens | |
| 1.4.3.4 | 0.0002 | - |
8-(3-chlorostyryl)caffeine | monoamine oxidase B | Mus musculus | |
| 1.4.3.4 | 0.0007 | - |
1,4-diphenyl-2-butene | monoamine oxidase B | Homo sapiens | |
| 1.4.3.4 | 0.0011 | - |
8-(3-chlorostyryl)caffeine | monoamine oxidase B | Rattus norvegicus | |
| 1.4.3.4 | 0.0014 | - |
8-(3-chlorostyryl)caffeine | monoamine oxidase B | Equus caballus | |
| 1.4.3.4 | 0.0023 | - |
trans,trans-farnesol | monoamine oxidase B | Homo sapiens | |
| 1.4.3.4 | 0.003 | - |
isatin | monoamine oxidase B | Homo sapiens | |
| 1.4.3.4 | 0.006 | - |
isatin | monoamine oxidase B | Bos taurus | |
| 1.4.3.4 | 0.006 | - |
1,4-diphenyl-2-butene | monoamine oxidase B | Rattus norvegicus | |
| 1.4.3.4 | 0.0083 | - |
1,4-diphenyl-2-butene | monoamine oxidase B | Equus caballus | |
| 1.4.3.4 | 0.015 | - |
isatin | monoamine oxidase A | Homo sapiens | |
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Release 2023.1 (January 2023)
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