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Literature summary extracted from

  • Turkish, A.R.; Henneberry, A.L.; Cromley, D.; Padamsee, M.; Oelkers, P.; Bazzi, H.; Christiano, A.M.; Billheimer, J.T.; Sturley, S.L.
    Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily (2005), J. Biol. Chem., 280, 14755-14764.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.20 gene DC3, location of DC3 on the X chromosome at Xq13.1, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae Homo sapiens
2.3.1.20 gene DGAT2, localization of DGAT2 at 11q13.5, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae Homo sapiens
2.3.1.75 gene AWAT1, i.e. DGA2, location on the X chromosome Xq13.1, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae Homo sapiens
2.3.1.75 gene DC3, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae Homo sapiens
2.3.1.75 gene DC4, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae Homo sapiens
2.3.1.75 gene DC4, i.e. AWAT2, location on the X chromosome Xq13.1, DNA and amino acid sequence determination and analysis, expression analysis, expression in Saccharomyces cerevisiae Homo sapiens
2.3.1.75 gene DGAT2, DNA and amino acid sequence determination and analysis, genetic organization and phylogenetics, expression in Saccharomyces cerevisiae Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.75 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.20 Mg2+
-
 Homo sapiens
2.3.1.75 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.75 acyl-CoA + long-chain diacylglycerol Homo sapiens
-
 CoA + long-chain triacylglycerol
-
 ?
2.3.1.75 acyl-CoA + long-chain fatty alcohol Homo sapiens
-
 CoA + long-chain fatty ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Homo sapiens
-
-
-
2.3.1.20 Homo sapiens Q6ZPD8 gene DC3; X-linked gene DC3
-
2.3.1.20 Homo sapiens Q96PD7 gene DGAT2; gene DGAT2
-
2.3.1.75 Homo sapiens Q58HT5 AWAT1, i.e. DGA2; X-linked gene AWAT1/DGA2
-
2.3.1.75 Homo sapiens Q58HT5 gene DGAT2L3; isozyme DGA2 or AWAT1
-
2.3.1.75 Homo sapiens Q6E213 AWAT2, i.e. DC4; X-linked genes AWAT1/DGA2 and AWAT2/DC4
-
2.3.1.75 Homo sapiens Q6E213 gene DGAT2L4; isozyme DC4 or AWAT2
-
2.3.1.75 Homo sapiens Q6ZPD8 gene DGAT2L6; isozyme DC3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.20 skin predominant expression of DC3 Homo sapiens
-
2.3.1.75 additional information tissue distribution of DC3 expression, overview Homo sapiens
-
2.3.1.75 additional information tissue distribution of DC4 expression, overview Homo sapiens
-
2.3.1.75 additional information tissue distribution of DGA2 expression, overview Homo sapiens
-
2.3.1.75 skin predominant expression Homo sapiens
-
2.3.1.75 skin predominant expression of AWAT1 Homo sapiens
-
2.3.1.75 skin predominant expression of AWAT2 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.75 additional information
-
-
 Homo sapiens
2.3.1.75 additional information
-
 substrate specificity, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.20 1,2-dioleoylglycerol + oleoyl-CoA
-
 Homo sapiens triolein + CoA
-
 ?
2.3.1.75 acyl-CoA + long-chain diacylglycerol
-
 Homo sapiens CoA + long-chain triacylglycerol
-
 ?
2.3.1.75 acyl-CoA + long-chain fatty alcohol
-
 Homo sapiens CoA + long-chain fatty ester
-
 ?
2.3.1.75 cetyl alcohol + oleoyl-CoA
-
 Homo sapiens CoA + cetyloleate
-
 ?
2.3.1.75 linear long-chain alcohol + oleoyl-CoA
-
 Homo sapiens ?
-
 ?
2.3.1.75 linear long-chain alcohol + palmitoleoyl-CoA
-
 Homo sapiens ?
-
 ?
2.3.1.75 linear long-chain alcohol + palmitoyl-CoA
-
 Homo sapiens ?
-
 ?
2.3.1.75 linear long-chain alcohol + stearoyl-CoA
-
 Homo sapiens ?
-
 ?
2.3.1.75 additional information AWAT 1 predominantly esterifies long chain, wax alcohols with acyl-CoA-derived fatty acids to produce wax esters, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation, overview Homo sapiens ?
-
 ?
2.3.1.75 additional information AWAT 2 predominantly esterifies long chain, wax alcohols with acyl-CoA-derived fatty acids to produce wax esters, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation, overview, no activity of AWAT2 with 1-decanol Homo sapiens ?
-
 ?
2.3.1.75 additional information bifunctional enzyme also catalyzing the reaction of EC 2.3.1.20 Homo sapiens ?
-
 ?
2.3.1.75 additional information substrate specificity of AWAT1, overview, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation and predominantly esterify long chain alcohols with acyl-CoA-derived fatty acids to produce wax esters, bifunctional enzyme also catalyzing the reaction of EC 2.3.1.20 Homo sapiens ?
-
 ?
2.3.1.75 additional information substrate specificity of AWAT2, overview, AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation and predominantly esterify long chain alcohols with acyl-CoA-derived fatty acids to produce wax esters, bifunctional enzyme also catalyzing the reaction of EC 2.3.1.20 Homo sapiens ?
-
 ?
2.3.1.75 oleoyl-CoA + (9Z)-hexadec-9-en-1-ol
-
 Homo sapiens CoA + (9Z)-hexadec-9-en-1-yl (9Z)-octadec-9-enoate
-
 ?
2.3.1.75 oleoyl-CoA + 1-decanol
-
 Homo sapiens CoA + decyl oleate
-
 ?
2.3.1.75 oleoyl-CoA + 1-octadecanol
-
 Homo sapiens CoA + octadecyl oleate
-
 ?
2.3.1.75 oleoyl-CoA + cetyl alcohol
-
 Homo sapiens CoA + cetyl oleate
-
 ?
2.3.1.75 oleoyl-CoA + decanol
-
 Homo sapiens CoA + decyl oleate
-
 ?
2.3.1.75 oleoyl-CoA + eicosanol
-
 Homo sapiens CoA + icosyl (9Z)-octadec-9-enoate
-
 ?
2.3.1.75 oleoyl-CoA + oleic alcohol
-
 Homo sapiens CoA + (9Z)-octadec-9-en-1-yl (9Z)-octadec-9-enoate
-
 ?
2.3.1.75 palmitoleoyl-CoA + cetyl alcohol
-
 Homo sapiens CoA + cetyl palmitoleate
-
 ?
2.3.1.75 palmitoleyl alcohol + oleoyl-CoA
-
 Homo sapiens CoA + palmitoleyl oleate
-
 ?
2.3.1.75 palmitoyl-CoA + cetyl alcohol
-
 Homo sapiens CoA + cetyl palmitate
-
 ?
2.3.1.75 stearoyl-CoA + cetyl alcohol
-
 Homo sapiens CoA + cetyl stearate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.20 acyl-CoA:diacylglycerol acyltransferase
-
 Homo sapiens
2.3.1.20 DC3
-
 Homo sapiens
2.3.1.20 DGAT2
-
 Homo sapiens
2.3.1.20 More cf. EC 2.3.1.75, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase, DGAT, 2 gene superfamily Homo sapiens
2.3.1.75 acyl-CoA wax alcohol acyltransferase
-
 Homo sapiens
2.3.1.75 acyl-CoA wax alcohol acyltransferases
-
 Homo sapiens
2.3.1.75 AWAT
-
 Homo sapiens
2.3.1.75 AWAT 1
-
 Homo sapiens
2.3.1.75 AWAT 2
-
 Homo sapiens
2.3.1.75 More cf. EC 2.3.1.20, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase, DGAT, 2 gene superfamily Homo sapiens
2.3.1.75 More the enzyme belongs to the diacylglycerol acyltransferase 2, DGAT2, gene superfamily, cf. EC 2.3.1.20 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.20 37
-
 assay at Homo sapiens
2.3.1.75 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.20 7.5
-
 assay at Homo sapiens
2.3.1.75 7.5
-
 assay at Homo sapiens