Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, X.; Maiti, S.; Zhang, J.; Chen, G.
    Nuclear receptor interactions in methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) (2006), J. Biochem. Mol. Toxicol., 20, 309-317.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.15 additional information methotrexate induces SULT2A1 expression via nuclear receptor interactions, molecular mechanism, overview, the constitutive active receptor, CAR, mediates the methotrexate induction of SULT2A1 in both Caco-2 and Hep G2 cells, vitamin D receptor, VDR, also upregulates SULT2A1 gene expression, CAR inhibits VDR-mediated vitaminD3 induction of SULT2A1 but notmethotrexate induction of SULT2A1, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.15 SULT2A1, determination of the promoter sequence, SULT2A1-reporter gene expression in Hep-G2 cells and expression analysis, the constitutive active receptor, CAR, mediates the methotrexate induction of SULT2A1 in both Caco-2 andHep G2 cells, vitamin D receptor, VDR, also upregulates SULT2A1 gene expression, while human pregnane X receptor, PXR, downregulates it Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.15 additional information human pregnane X receptor, PXR, downregulates SULT2A1 gene expression, overview, CAR inhibites VDR-mediated vitamin D3 induction of SULT2A1 but notmethotrexate induction of SULT2A1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
 adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
 ?
2.8.2.15 additional information Homo sapiens SULT2A1 plays a very important role in sulfating endogenous hydroxysteroids and exogenousxenobiotics ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.15 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-O-sulfate
-
 ?
2.8.2.15 additional information SULT2A1 plays a very important role in sulfating endogenous hydroxysteroids and exogenousxenobiotics Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 dehydroepiandrosterone sulfotransferase
-
 Homo sapiens
2.8.2.15 SULT2A1
-
 Homo sapiens