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Literature summary extracted from
- Heterogeneity of the coumarin anticoagulant targeted vitamin K epoxide reduction system. Study of kinetic parameters in susceptible and resistant mice (Mus musculus domesticus) (2006), J. Biochem. Mol. Toxicol., 20, 221-229.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.17.4.4 | gene VKORC1, genotyping | Mus musculus |
| 1.17.4.4 | gene VKORC1, genotyping | Mus musculus domesticus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.17.4.4 | W59G | the single nucleotide polymorphism T175G in gene VKORC1 causes 4-hydroxycoumarin derivative-resistance | Mus musculus domesticus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.4 | additional information | mechanism of 4-hydroxycoumarin derivative-resistance, overview | Mus musculus domesticus | |
| 1.17.4.4 | warfarin | inhibition mechanism, overview | Mus musculus |  |
| 1.17.4.4 | warfarin | slight inhibition, mechanism, overview | Mus musculus domesticus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.4.4 | additional information | - |
additional information | kinetics | Mus musculus | |
| 1.17.4.4 | additional information | - |
additional information | kinetics | Mus musculus domesticus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.17.4.4 | microsome | - |
Mus musculus | - |
- |
| 1.17.4.4 | microsome | - |
Mus musculus domesticus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Mus musculus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Mus musculus domesticus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.4.4 | Mus musculus | - |
warfarin-susceptible strain | - |
| 1.17.4.4 | Mus musculus domesticus | - |
warfarin-resistant strain | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.17.4.4 | partially by microsome preparation | Mus musculus |
| 1.17.4.4 | partially by microsome preparation | Mus musculus domesticus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.17.4.4 | liver | - |
Mus musculus | - |
| 1.17.4.4 | liver | - |
Mus musculus domesticus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Mus musculus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Mus musculus domesticus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.17.4.4 | vitamin K epoxide reductase | - |
Mus musculus |
| 1.17.4.4 | vitamin K epoxide reductase | - |
Mus musculus domesticus |
| 1.17.4.4 | VKOR | - |
Mus musculus |
| 1.17.4.4 | VKOR | - |
Mus musculus domesticus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.17.4.4 | 30 | - |
assay at | Mus musculus |
| 1.17.4.4 | 30 | - |
assay at | Mus musculus domesticus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.17.4.4 | 7.4 | - |
assay at | Mus musculus |
| 1.17.4.4 | 7.4 | - |
assay at | Mus musculus domesticus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.4.4 | additional information | - |
additional information | inhibition kinetics | Mus musculus | |
| 1.17.4.4 | additional information | - |
additional information | inhibition kinetics | Mus musculus domesticus | |
| 1.17.4.4 | 0.006 | - |
warfarin | pH 7.4, 30°C | Mus musculus | |
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Release 2023.1 (January 2023)
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