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Literature summary extracted from
- Warfarin resistance in a french strain of rats (2005), J. Biochem. Mol. Toxicol., 19, 379-385.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.17.4.4 | gene VKORC1 Y139F, DNA and amino acid sequence determination, genotyping, semiquantitative expression analysis | Rattus norvegicus |
| 1.17.4.4 | gene VKORC1, DNA and amino acid sequence determination, genotyping, semiquantitative expression analysis | Rattus norvegicus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.17.4.4 | Y139F | the natural occuring mutation confers resistance to enzyme inhibitor warfarin, the mutant rats do not show vitamin K deficiency | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.4 | warfarin | the mutant Y139F strain is resistant to warfarin; wild-type rats | Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.4.4 | additional information | - |
additional information | kinetics | Rattus norvegicus | |
| 1.17.4.4 | 0.0195 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 25°C | Rattus norvegicus | |
| 1.17.4.4 | 0.0577 | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone | pH 7.4, 25°C | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.17.4.4 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.4.4 | Rattus norvegicus | - |
gene VKORC1, mutant Y139F | - |
| 1.17.4.4 | Rattus norvegicus | Q6TEK4 | warfarin-susceptible rats; gene VKORC1 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.4 | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.17.4.4 | VKOR | - |
Rattus norvegicus |
| 1.17.4.4 | VKORC1 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.17.4.4 | 25 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.17.4.4 | 7.4 | - |
assay at | Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.17.4.4 | additional information | - |
additional information | inhibition kinetics | Rattus norvegicus | |
| 1.17.4.4 | 0.00072 | - |
warfarin | pH 7.4, 25°C | Rattus norvegicus | |
| 1.17.4.4 | 0.029 | - |
warfarin | pH 7.4, 25°C | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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