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Literature summary extracted from

  • Ikeguchi, Y.; Bewley, M.C.; Pegg, A.E.
    Aminopropyltransferases: function, structure and genetics (2006), J. Biochem., 139, 1-9.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.22 1-aminooxy-3-N-(3-aminopropyl)-aminopropane competitive inhibitor Mus musculus
2.5.1.22 3-(RS)-(5'-deoxy-5'-carbaadenos-6'-yl)spermidine IC50: 750 nM Mus musculus
2.5.1.22 N-(3-aminopropyl)cyclohexylamine IC50: 0.2 mM Mus musculus
2.5.1.22 N-butyl-1,3-diaminopropane IC50: 0.4 mM Mus musculus
2.5.1.22 N-[(2-aminooxyethyl)-1,4-diaminobutane] competitive inhibitor Mus musculus
2.5.1.22 S-adenosyl-1,12-diamino-3-thio-9-azadodecane IC50: 20 nM Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.22 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.22 S-adenosyl-L-methioninamine + spermidine
-
 Mus musculus 5'-methylthioadenosine + spermine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.22 SpmS
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.22 0.0015
-
 1-aminooxy-3-N-(3-aminopropyl)-aminopropane
-
 Mus musculus
2.5.1.22 0.186
-
 N-[(2-aminooxyethyl)-1,4-diaminobutane]
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.22 0.00002
-
 IC50: 20 nM Mus musculus S-adenosyl-1,12-diamino-3-thio-9-azadodecane
2.5.1.22 0.00075
-
 IC50: 750 nM Mus musculus 3-(RS)-(5'-deoxy-5'-carbaadenos-6'-yl)spermidine
2.5.1.22 0.2
-
 IC50: 0.2 mM Mus musculus N-(3-aminopropyl)cyclohexylamine
2.5.1.22 0.4
-
 IC50: 0.4 mM Mus musculus N-butyl-1,3-diaminopropane