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Literature summary extracted from

  • Lee, S.W.; Rho, M.C.; Park, H.R.; Choi, J.H.; Kang, J.Y.; Lee, J.W.; Kim, K.; Lee, H.S.; Kim, Y.K.
    Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum (2006), J. Agric. Food Chem., 54, 9759-9763.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.20 (2E)-1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)hex-4-en-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one IC50: 0.0098 mM Rattus norvegicus
2.3.1.20 (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine IC50: 0.0298 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus
2.3.1.20 dehydropipernonaline noncompetitive inhibition, IC50: 0.0212 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus
2.3.1.20 additional information inhibition mechanism, the inhibitory activity of Piper fruits is influenced by the presence of the piperidine group rather than by isobutyl group, overview Rattus norvegicus
2.3.1.20 oleoyl-CoA substrate inhibition Rattus norvegicus
2.3.1.20 pipernonaline IC50: 0.0372 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus
2.3.1.20 piperrolein B IC50: 0.0201 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus
2.3.1.20 retrofractamide C IC50: 0.9 mM, above, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.20 0.0046
-
 oleoyl-CoA pH 8.0, 25°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.20 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.20 Mg2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.20 liver
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.20 DGAT
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.20 25
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.20 8
-
 assay at Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.20 additional information
-
 additional information inhibition kinetics Rattus norvegicus
2.3.1.20 0.0054
-
 oleoyl-CoA pH 8.0, 25°C Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.20 0.0098
-
 IC50: 0.0098 mM Rattus norvegicus (2E)-1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)hex-4-en-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
2.3.1.20 0.0201
-
 IC50: 0.0201 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus piperrolein B
2.3.1.20 0.0212
-
 noncompetitive inhibition, IC50: 0.0212 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus dehydropipernonaline
2.3.1.20 0.0298
-
 IC50: 0.0298 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine
2.3.1.20 0.0372
-
 IC50: 0.0372 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus pipernonaline
2.3.1.20 0.9
-
 IC50: 0.9 mM, above, isolated from the extracts of fruits of Piper longum and Piper nigrum Rattus norvegicus retrofractamide C