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Literature summary extracted from

  • Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Banez-Coronel, M.; Megias, D.; Lacal, J.C.
    Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism (2005), Int. J. Oncol., 26, 999-1008.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.32 MN58b specific inhibitor, IC50: 0.0005-0.072 mM depending on cell type Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.32 breast adenocarcinoma cell
-
 Homo sapiens
-
2.7.1.32 cervical adenocarcinoma cell
-
 Homo sapiens
-
2.7.1.32 colonic adenocarcinoma cell
-
 Homo sapiens
-
2.7.1.32 epidermoid carcinoma cell
-
 Homo sapiens
-
2.7.1.32 erythroleukemia cell
-
 Homo sapiens
-
2.7.1.32 fibroblast
-
 Homo sapiens
-
2.7.1.32 lymphoma cell
-
 Homo sapiens
-
2.7.1.32 mammary epithelium
-
 Homo sapiens
-
2.7.1.32 myeloma cell
-
 Homo sapiens
-
2.7.1.32 osteosarcoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
-
 Homo sapiens ADP + O-phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 ChoK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.32 ATP
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.32 0.0005 0.072 specific inhibitor, IC50: 0.0005-0.072 mM depending on cell type Homo sapiens MN58b