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Literature summary extracted from

  • Feksa, L.R.; Cornelio, A.; Dutra-Filho, C.S.; Wyse, A.T.; Wajner, M.; Wannmacher, C.M.
    The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats (2005), Int. J. Dev. Neurosci., 23, 509-514.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.40 cystine 2.5 mM, significant inhibition Rattus norvegicus
2.7.1.40 L-phenylalanine 3 mM, significant inhibition Rattus norvegicus
2.7.1.40 L-tryptophan 1 mM, significant inhibition Rattus norvegicus
2.7.1.40 additional information alanine and serine cause no affection of activity but prevent the inhibition caused by phenylalanine, tryptophan or cystine Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.40 0.07
-
 phosphoenolpyruvate apparent value Rattus norvegicus
2.7.1.40 1.05
-
 ADP apparent value Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.40 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.40 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.40 ADP + phosphoenolpyruvate
-
 Rattus norvegicus ATP + pyruvate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.40 ADP
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.40 1.9
-
 tryptophan apparent value Rattus norvegicus