EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.1 | imatinib mesylate | potent inhibitor | Homo sapiens | |
2.7.10.1 | phosphotyrosyl phosphatase Shp1 | Shp1 binds to c-Kit at Y570 and acts by dephosphorylating the receptor directly, or inhibits c-Kit signalling indirectly by dephosphorylating other receptor-associated protein-tyrosine kinases | Homo sapiens | |
2.7.10.1 | Protein kinase C | subsequently phosphorylates c-Kit on specific serine residues leading to negative regulation of c-Kit activation | Homo sapiens | |
2.7.10.1 | STI571 | commercial Gleevec/Glivec, specific inhibitor | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.1 | ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.10.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.10.1 | hematopoietic stem cell | - |
Homo sapiens | - |
2.7.10.1 | mast cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.1 | ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.10.1 | c-kit | - |
Homo sapiens |
2.7.10.1 | c-Kit RTK | - |
Homo sapiens |
2.7.10.1 | CD117 | - |
Homo sapiens |
2.7.10.1 | stem cell factor receptor | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.1 | ATP | - |
Homo sapiens |