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Literature summary extracted from

  • Temmink, O.H.; de Bruin, M.; Laan, A.C.; Turksma, A.W.; Cricca, S.; Masterson, A.J.; Noordhuis, P.; Peters, G.J.
    The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells (2006), Int. J. Biochem. Cell Biol., 38, 1759-1765.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 5-benzylacyclouridine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 additional information Homo sapiens thymidine phosphorylase and uridine phosphorylase contribute in the conversion of 5'-deoxy-5-fluorouridine into 5-fluorouracil and the conversion of 5-fluorouracil into its active metabolites in peripheral blood mononuclear cell, but thymidine phosphorylase seems to be the most important enzyme for these reactions in PBMC ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-
2.4.2.4 Homo sapiens P19971
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 peripheral blood mononuclear cell
-
 Homo sapiens
-
2.4.2.4 peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.4 additional information thymidine phosphorylase and uridine phosphorylase contribute in the conversion of 5'-deoxy-5-fluorouridine into 5-fluorouracil and the conversion of 5-fluorouracil into its active metabolites in peripheral blood mononuclear cell, but thymidine phosphorylase seems to be the most important enzyme for these reactions in PBMC Homo sapiens ?
-
 ?