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Literature summary extracted from

  • Keith, K.E.; Valvano, M.A.
    Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia (2007), Infect. Immun., 75, 2451-2460.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.15.1.1 gene sodC, subcloning in Escherichia coli, complementation of the sodC mutant, expression of a SodC-FLAG fusion protein in strain K56-2 Burkholderia cenocepacia

Protein Variants

EC Number Protein Variants Comment Organism
1.15.1.1 additional information enzyme null mutant cell is not sensitive to H2O2, 3-morpholinosydnonimine, or paraquat challenge, but is killed by exogenous superoxide generated by the xanthine/xanthine oxidase method Burkholderia cenocepacia
1.15.1.1 additional information construction of a sodC null mutant strain KEK1, which is not sensitive to a H2O2, 3-morpholinosydnonimine, or paraquat challenge, but is killed by exogenous superoxide generated by the xanthine/xanthine oxidase method. The sodC mutant also exhibits a growth defect in liquid medium compared to the parental strain, which can be complemented in trans. The mutant organism is killed more rapidly than the parental strain in murine macrophage-like cell line RAW 264.7, but killing is eliminated when macrophages are treated with an NADPH oxidase inhibitor, overview Burkholderia cenocepacia

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 additional information enzyme is not inhibited by H2O2 and unusually resistant to KCN; SodC is resistant to inhibition by H2O2 and is unusually resistant to KCN for a Cu,Zn-SOD Burkholderia cenocepacia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 periplasm
-
 Burkholderia cenocepacia
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 copper
-
 Burkholderia cenocepacia
1.15.1.1 Cu2+ a Cu,ZnSOD Burkholderia cenocepacia
1.15.1.1 Zinc
-
 Burkholderia cenocepacia
1.15.1.1 Zn2+ a Cu,ZnSOD Burkholderia cenocepacia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 O2.- + H+ Burkholderia cenocepacia periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ Burkholderia cenocepacia K56-2 periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Burkholderia cenocepacia
-
-
-
1.15.1.1 Burkholderia cenocepacia K56-2
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2.- + H+
-
 Burkholderia cenocepacia O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages Burkholderia cenocepacia O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+
-
 Burkholderia cenocepacia K56-2 O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ periplasmic Cu,ZnSOD protects the bacterium from exogenously generated O2.- and contributes to intracellular survival of the bacterium in macrophages Burkholderia cenocepacia K56-2 O2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 Cu,ZnSOD
-
 Burkholderia cenocepacia
1.15.1.1 SodC
-
 Burkholderia cenocepacia