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Literature summary extracted from

  • Erova, T.E.; Pillai, L.; Fadl, A.A.; Sha, J.; Wang, S.; Galindo, C.L.; Chopra, A.K.
    DNA adenine methyltransferase influences the virulence of Aeromonas hydrophila (2006), Infect. Immun., 74, 410-424.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.72 medicine essential for the viability of the bacterium, overproduction of Dam in Aeromonas hydrophila SSU reduces the virulence of the pathogen, decreases the motility and T3SS-associated cytotoxicity, but increases both the cytotoxicity and hemolysis associated with Act, mice infected with the Dam-overproducing strain do not die over a tested period of 3 weeks, indicating bacterial attenuation as a result of Dam overproduction Aeromonas hydrophila

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.72 in a T7 promoter-based vector system using Escherichia coli ER2566 as a host strain, which can alter the virulence potential Aeromonas hydrophila

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.72 additional information strain SSU dam chromosomal deletion mutant, is not viable Aeromonas hydrophila

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.72 32662
-
 1 * 34000, SDS-PAGE, 1 * 32662, sequence analysis Aeromonas hydrophila
2.1.1.72 34000
-
 1 * 34000, SDS-PAGE, 1 * 32662, sequence analysis Aeromonas hydrophila

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.72 Aeromonas hydrophila
-
-
-
2.1.1.72 Aeromonas hydrophila SSU
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.72 by nickel affinity chromatography Aeromonas hydrophila

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine
-
 Aeromonas hydrophila S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine
-
 Aeromonas hydrophila SSU S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.72 ? 1 * 34000, SDS-PAGE, 1 * 32662, sequence analysis Aeromonas hydrophila

Synonyms

EC Number Synonyms Comment Organism
2.1.1.72 Dam
-
 Aeromonas hydrophila
2.1.1.72 DNA adenine methyltransferase
-
 Aeromonas hydrophila