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Literature summary extracted from

  • Wang, J.; Olin, M.; Rozell, B.; Bjoerkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
    Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse (2007), Histochem. Cell Biol., 127, 253-261.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.23 Cyp7a1 expression pattern in wild-type and Cyp8b1 null mice livers, overview Mus musculus
1.14.14.139 gene CYP8B1, expression analysis in liver tissues of wild-type, regulation of gene expression, overview Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.139 additional information construction of CYP8B1 null mice which show increased expression of cholesterol 7alpha-hydroxylase, CYP7A1, EC 1.14.13.17 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.139 additional information cholate supresses enzyme expression Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.23 microsome
-
 Mus musculus
-
-
1.14.14.139 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus the enzyme is necessary for the synthesis of cholic acid 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.23 Mus musculus
-
 wild-type C57Bl/6 and male Cyp8b1 knockout mice on a mixed 129Sv/Ev-C57Bl/6 background
-
1.14.14.139 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.23 hepatocyte
-
 Mus musculus
-
1.14.14.23 liver Cyp7a1 expression pattern in wild-type and Cyp8b1 null mice livers, Cyp7a1 expression in wild type mice shows a zonal distribution pattern, Cyp8b1 knockout mice show increased expression of Cyp7a1, overview Mus musculus
-
1.14.14.139 liver enzyme expression pattern within the liver architecture, zonal distribution pattern, overview Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme is necessary for the synthesis of cholic acid Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.23 cholesterol 7alpha-hydroxylase
-
 Mus musculus
1.14.14.23 CYP7A1
-
 Mus musculus
1.14.14.139 CYP8B1
-
 Mus musculus
1.14.14.139 sterol 12alpha-hydroxylase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.23 NADPH
-
 Mus musculus