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Literature summary extracted from

  • Seidah, N.G.; Chretien, M.
    Proprotein convertase SKI-1/SIP (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press, 2, 1845-1847.
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.112 additional information complete silencing of SKI-1/SP1 results in an embryonic lethal phenotype, elimination of about 70-90% of SKI-1/SP1 protein expression in liver results in a drop of ca. 50% in the level of circulating cholesterol and triglycerides, cholesterol and fatty acid biosynthesis in hepatocytes declines by 75%, low density lipoprotein receptor mRNA declines by 50% Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.112 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.4.21.112 membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.112 98000
-
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.112 Arabidopsis thaliana
-
-
-
3.4.21.112 Cricetulus griseus
-
-
-
3.4.21.112 Homo sapiens
-
-
-
3.4.21.112 Mus musculus
-
-
-
3.4.21.112 Oryza sativa
-
-
-
3.4.21.112 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.112 hepatocyte
-
 Mus musculus
-
3.4.21.112 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.112 Abz-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-(3-nitro)Tyr-Ala-NH2 + H2O favored quenched fluorogenic substrate Homo sapiens ?
-
 ?
3.4.21.112 ATF6 + H2O i.e. activating transcription factor 6 Cricetulus griseus ?
-
 ?
3.4.21.112 Crimean Congo hemorrhagic fever virus glycoprotein + H2O cleavage at RRLL-sites Homo sapiens ?
-
 ?
3.4.21.112 Lassa virus glycoprotein + H2O cleavage at RRLL-sites Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.112 SKI-1/S1P
-
 Cricetulus griseus
3.4.21.112 SKI-1/S1P
-
 Mus musculus
3.4.21.112 SKI-1/S1P
-
 Homo sapiens
3.4.21.112 SKI-1/S1P
-
 Rattus norvegicus
3.4.21.112 SKI-1/S1P
-
 Arabidopsis thaliana
3.4.21.112 SKI-1/S1P
-
 Oryza sativa
3.4.21.112 subtilisin kexin-isozyme-1
-
 Homo sapiens