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Literature summary extracted from

  • Moriwaki, K.; Noda, K.; Nakagawa, T.; Asahi, M.; Yoshihara, H.; Taniguchi, N.; Hayashi, N.; Miyoshi, E.
    A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation (2007), Glycobiology, 17, 1311-1320.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.271 quantitative RT-PCR expression analysis of the enzyme in liver and hepatocarcinomas, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.271 cytosol
-
 Homo sapiens 5829
-
2.7.7.30 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.271 additional information Homo sapiens fucosylation is regulated by complicated mechanisms that involve several factors: fucosyltransferases, GDP-fucose transporter, and GDP-fucose-synthetic enzymes, such as GDP-mannose 4,6-dehydratase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, and GDP-fucose pyrophosphorylase, fucose metabolism, overview ?
-
 ?
2.7.7.30 L-fucose 1-phosphate + GTP Homo sapiens salvage pathway GDP-L-fucose + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.271 Homo sapiens
-
-
-
2.7.7.30 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.271 hepatocellular carcinoma cell increased enzyme expression compared with adjacent tissue or the tissue of healthy livers, quantitative RT-PCR expression analysis, overview Homo sapiens
-
1.1.1.271 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.271 additional information fucosylation is regulated by complicated mechanisms that involve several factors: fucosyltransferases, GDP-fucose transporter, and GDP-fucose-synthetic enzymes, such as GDP-mannose 4,6-dehydratase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, and GDP-fucose pyrophosphorylase, fucose metabolism, overview Homo sapiens ?
-
 ?
2.7.7.30 L-fucose 1-phosphate + GTP salvage pathway Homo sapiens GDP-L-fucose + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.271 GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase
-
 Homo sapiens
2.7.7.30 GDP-fucose pyrophosphorylase
-
 Homo sapiens