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Literature summary extracted from

  • Julien, S.; Adriaenssens, E.; Ottenberg, K.; Furlan, A.; Courtand, G.; Vercoutter-Edouart, A.S.; Hanisch, F.G.; Delannoy, P.; Le Bourhis, X.
    ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity (2006), Glycobiology, 16, 54-64.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.3 stable transfection of the breast cancer cell line MDA-MB-231 with ST6GalNAc I cDNA induces sialyl-Tn antigen expression, modifications of the O-glycosylation pattern of a MUC1-related recombinant protein secreted by MDA-MB-231 sialyl-Tn positive cells occurs, sialyl-Tn expression and concomitant changes in the overall O-glycan profiles induce a decrease of adhesion and an increase of migration of MDA-MB-231, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.3 CMP-N-acetylneuraminate + protein MUC1-MFP6 Homo sapiens recombinant protein substrate expressed in MDA-MB-231 breast cancer cells, glycoprofiling, overview ?
-
?
2.4.3.3 additional information Homo sapiens the enzyme participates in the core O-glycan biosynthesis, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.3 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.3 CMP-N-acetylneuraminate + protein MUC1-MFP6 recombinant protein substrate expressed in MDA-MB-231 breast cancer cells, glycoprofiling, overview Homo sapiens ?
-
?
2.4.3.3 CMP-N-acetylneuraminate + protein MUC1-MFP6 recombinant protein substrate, glycoprofiling, overview Homo sapiens ?
-
?
2.4.3.3 additional information the enzyme participates in the core O-glycan biosynthesis, overview Homo sapiens ?
-
?
2.4.3.3 additional information the enzyme transfers a sialic acid residue in alpha-2,6-linkage to the GalNAcalpha1-O-Ser/Thr structure Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.3 CMP-Neu5Ac: RGalNAcalpha1-O-Ser/Thralpha2,6-sialyltransferase
-
Homo sapiens
2.4.3.3 CMPNeu5Ac:GalNAalpha2,6-sialyltransferase
-
Homo sapiens
2.4.3.3 ST6GalNAc I
-
Homo sapiens