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Literature summary extracted from

  • Price, M.A.
    CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling (2006), Genes Dev., 20, 399-410.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 overexpression of CKI in Drosophila Kc cell line, the sole Drosophila CKIdelta/epsilon gene, but not CKIalpha, activates a wingless transcriptional reporter in the absence of ligand Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.1 D173N the dominant-negative form of CKIgamma inhibits Wnt signaling in a reporter assay in 293T cells, and gish RNAi partially blocks transcription induced by Wg in SL2 cells Drosophila melanogaster
2.7.11.1 K73R the dominant-negative form of CKIgamma inhibits Wnt signaling in a reporter assay in 293T cells, and gish RNAi partially blocks transcription induced by Wg in SL2 cells Drosophila melanogaster
2.7.11.1 additional information injection of kinase-dead CKIepsilon into early Xenopus embryos causes defects in convergent extension during gastrulation Xenopus laevis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 CKI-7
-
 Xenopus laevis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + adenomatous polyposis coli protein Drosophila melanogaster i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon ADP + phosphorylated adenomatous polyposis coli protein
-
 ?
2.7.11.1 ATP + adenomatous polyposis coli protein Homo sapiens i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon ADP + phosphorylated adenomatous polyposis coli protein
-
 ?
2.7.11.1 ATP + adenomatous polyposis coli protein Xenopus laevis i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon ADP + phosphorylated adenomatous polyposis coli protein
-
 ?
2.7.11.1 ATP + beta-catenin Drosophila melanogaster phosphorylation at Ser45, priming GSK3beta phosphorylation ADP + phosphorylated beta-catenin
-
 ?
2.7.11.1 ATP + beta-catenin Homo sapiens phosphorylation at Ser45, priming GSK3beta phosphorylation ADP + phosphorylated beta-catenin
-
 ?
2.7.11.1 ATP + beta-catenin Xenopus laevis phosphorylation at Ser45, priming GSK3beta phosphorylation ADP + phosphorylated beta-catenin
-
 ?
2.7.11.1 ATP + Gli protein Homo sapiens the Gli proteins are important in regulation of Hedgehog signaling, overview ADP + phosphorylated Gli protein
-
 ?
2.7.11.1 ATP + protein Cubitus interruptus Drosophila melanogaster Ci proteins are important in regulation of Hedgehog signaling, overview ADP + phosphorylated protein Cubitus interruptus
-
 ?
2.7.11.1 ATP + protein Cubitus interruptus Xenopus laevis Ci proteins are important in regulation of Hedgehog signaling, overview ADP + phosphorylated protein Cubitus interruptus
-
 ?
2.7.11.1 ATP + protein LRP6 Drosophila melanogaster CKIgamma ADP + phosphorylated protein LRP6
-
 ?
2.7.11.1 ATP + protein LRP6 Homo sapiens CKIgamma ADP + phosphorylated protein LRP6
-
 ?
2.7.11.1 ATP + protein LRP6 Xenopus laevis CKIgamma ADP + phosphorylated protein LRP6
-
 ?
2.7.11.1 ATP + protein TCF3 Drosophila melanogaster CKIepsilon ADP + phosphorylated protein TCF3
-
 ?
2.7.11.1 ATP + protein TCF3 Homo sapiens CKIepsilon ADP + phosphorylated protein TCF3
-
 ?
2.7.11.1 ATP + protein TCF3 Xenopus laevis CKIepsilon ADP + phosphorylated protein TCF3
-
 ?
2.7.11.1 additional information Drosophila melanogaster multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase ?
-
 ?
2.7.11.1 additional information Homo sapiens multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase ?
-
 ?
2.7.11.1 additional information Xenopus laevis multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Drosophila melanogaster
-
 isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon
-
2.7.11.1 Homo sapiens
-
 isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon
-
2.7.11.1 Xenopus laevis
-
 isozymes alpha, beta, gamma1, gamm2, gamma3, delta, and epsilon
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 cell culture
-
 Xenopus laevis
-
2.7.11.1 embryo
-
 Xenopus laevis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + adenomatous polyposis coli protein i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon Drosophila melanogaster ADP + phosphorylated adenomatous polyposis coli protein
-
 ?
2.7.11.1 ATP + adenomatous polyposis coli protein i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon Homo sapiens ADP + phosphorylated adenomatous polyposis coli protein
-
 ?
2.7.11.1 ATP + adenomatous polyposis coli protein i.e. APC, APC is phosphorylated in vitro by CKIdelta and CKIepsilon Xenopus laevis ADP + phosphorylated adenomatous polyposis coli protein
-
 ?
2.7.11.1 ATP + beta-catenin phosphorylation at Ser45, priming GSK3beta phosphorylation Drosophila melanogaster ADP + phosphorylated beta-catenin
-
 ?
2.7.11.1 ATP + beta-catenin phosphorylation at Ser45, priming GSK3beta phosphorylation Homo sapiens ADP + phosphorylated beta-catenin
-
 ?
2.7.11.1 ATP + beta-catenin phosphorylation at Ser45, priming GSK3beta phosphorylation Xenopus laevis ADP + phosphorylated beta-catenin
-
 ?
2.7.11.1 ATP + Gli protein
-
 Homo sapiens ADP + phosphorylated Gli protein
-
 ?
2.7.11.1 ATP + Gli protein the Gli proteins are important in regulation of Hedgehog signaling, overview Homo sapiens ADP + phosphorylated Gli protein
-
 ?
2.7.11.1 ATP + protein Cubitus interruptus Ci proteins are important in regulation of Hedgehog signaling, overview Drosophila melanogaster ADP + phosphorylated protein Cubitus interruptus
-
 ?
2.7.11.1 ATP + protein Cubitus interruptus Ci proteins are important in regulation of Hedgehog signaling, overview Xenopus laevis ADP + phosphorylated protein Cubitus interruptus
-
 ?
2.7.11.1 ATP + protein Cubitus interruptus i.e. Ci, e.g. Ci-75 or Ci-155 Drosophila melanogaster ADP + phosphorylated protein Cubitus interruptus
-
 ?
2.7.11.1 ATP + protein Cubitus interruptus i.e. Ci, e.g. Ci-75 or Ci-155 Xenopus laevis ADP + phosphorylated protein Cubitus interruptus
-
 ?
2.7.11.1 ATP + protein LRP6 CKIgamma Drosophila melanogaster ADP + phosphorylated protein LRP6
-
 ?
2.7.11.1 ATP + protein LRP6 CKIgamma Homo sapiens ADP + phosphorylated protein LRP6
-
 ?
2.7.11.1 ATP + protein LRP6 CKIgamma Xenopus laevis ADP + phosphorylated protein LRP6
-
 ?
2.7.11.1 ATP + protein TCF3 CKIepsilon Drosophila melanogaster ADP + phosphorylated protein TCF3
-
 ?
2.7.11.1 ATP + protein TCF3 CKIepsilon Homo sapiens ADP + phosphorylated protein TCF3
-
 ?
2.7.11.1 ATP + protein TCF3 CKIepsilon Xenopus laevis ADP + phosphorylated protein TCF3
-
 ?
2.7.11.1 additional information multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase Drosophila melanogaster ?
-
 ?
2.7.11.1 additional information multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase Homo sapiens ?
-
 ?
2.7.11.1 additional information multiple CKI family members play a role in both positively and negatively regulating Wnt and Hedgehog signaling, and the regulation of the stability of cytoplasmic beta-catenin, detailed overview, the partial degradation of Ci is promoted by phosphorylation and by a cytoplasmic complex, which includes Costal-2, a microtubule-binding protein, and Fused, a serine-threonine protein kinase Xenopus laevis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.1 More outside of the kinase domain, CKI family members fall into subfamilies that have little homology to each other and differ in the length and amino acid sequence of their N- and C-terminal extensions Drosophila melanogaster
2.7.11.1 More outside of the kinase domain, CKI family members fall into subfamilies that have little homology to each other and differ in the length and amino acid sequence of their N- and C-terminal extensions Homo sapiens
2.7.11.1 More outside of the kinase domain, CKI family members fall into subfamilies that have little homology to each other and differ in the length and amino acid sequence of their N- and C-terminal extensions Xenopus laevis

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 casein kinase I
-
 Drosophila melanogaster
2.7.11.1 casein kinase I
-
 Homo sapiens
2.7.11.1 casein kinase I
-
 Xenopus laevis
2.7.11.1 More the enzyme belongs to the CKI family of serine/threonine protein kinases Drosophila melanogaster
2.7.11.1 More the enzyme belongs to the CKI family of serine/threonine protein kinases Homo sapiens
2.7.11.1 More the enzyme belongs to the CKI family of serine/threonine protein kinases Xenopus laevis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
 Drosophila melanogaster
2.7.11.1 ATP
-
 Homo sapiens
2.7.11.1 ATP
-
 Xenopus laevis