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Literature summary extracted from

  • Kitashiba, H.; Hao, Y.J.; Honda, C.; Moriguchi, T.
    Two types of spermine synthase gene: MdACL5 and MdSPMS are differentially involved in apple fruit development and cell growth (2005), Gene, 361, 101-111.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.16 gene ACL5-1, DNA and amino acid sequence determination and analysis, ACL5-1 complements Spm biosynthesis in an enzyme-deficient yeast mutant, and ectopic expression of ACL5-1 in the Arabidopsis thaliana dwarf mutant acl5 allows recovery of the normal phenotype Malus sylvestris
2.5.1.16 gene ACL5-2, DNA and amino acid sequence determination and analysis Malus sylvestris
2.5.1.16 gene SPMS, DNA and amino acid sequence determination and analysis, SPMS complements Spm biosynthesis in an enzyme-deficient yeast mutant Malus sylvestris
2.5.1.22 expressed in a yeast mutant deficient in Spm synthase, and in the Arabidopsis dwarf mutant acl5 Malus sylvestris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosylmethioninamine + putrescine Malus sylvestris functional ACL5 and SPMS are independently involved in apple fruit development and cell growth 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Malus sylvestris Q4ADY3 gene ACL5-2; var. domestica, genes ACL5-1 and ACL5-2, and SPMS
-
2.5.1.16 Malus sylvestris Q4ADY4 gene ACL5-1; var. domestica, genes ACL5-1 and ACL5-2, and SPMS
-
2.5.1.16 Malus sylvestris Q4ADY5 gene SPMS; var. domestica, genes ACL5-1 and ACL5-2, and SPMS
-
2.5.1.22 Malus sylvestris
-
 var. domestica
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 cell suspension culture
-
 Malus sylvestris
-
2.5.1.16 flower
-
 Malus sylvestris
-
2.5.1.16 fruit
-
 Malus sylvestris
-
2.5.1.16 leaf
-
 Malus sylvestris
-
2.5.1.16 additional information genes ACL5 and SPMS are differentially expressed in tissues and suspension cells, expression analysis, overview Malus sylvestris
-
2.5.1.22 flower
-
 Malus sylvestris
-
2.5.1.22 fruit
-
 Malus sylvestris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosylmethioninamine + putrescine functional ACL5 and SPMS are independently involved in apple fruit development and cell growth Malus sylvestris 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosylmethioninamine + putrescine Val149, Ser161, Ala205, and Val235 are involved in the S-adenosylmethioninamine binding Malus sylvestris 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?
2.5.1.22 S-adenosyl-L-methioninamine + spermidine
-
 Malus sylvestris 5'-methylthioadenosine + spermine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.16 SPDS
-
 Malus sylvestris
2.5.1.16 Spm synthase
-
 Malus sylvestris
2.5.1.22 ACL5
-
 Malus sylvestris
2.5.1.22 Spm synthase
-
 Malus sylvestris
2.5.1.22 SpmS
-
 Malus sylvestris