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Literature summary extracted from
- Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity (2006), Free Radic. Res., 40, 936-943.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | selenoprotein P | 2 nM, 3fold stimulation of activity after 24h | Homo sapiens | |
| 1.11.1.12 | Sodium selenite | 100 nM, 3fold stimulation of activity after 24h | Homo sapiens |  |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.11.1.9 | selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.9 | Mercaptosuccinate | - |
Homo sapiens | |
| 1.11.1.12 | Mercaptosuccinate | 0.1 mM | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.11.1.9 | cytosol | - |
Homo sapiens | 5829 | - |
| 1.11.1.12 | cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.9 | selenium | selenium supplementation by selenoprotein P prevents oxidative damage of human endothelial cells by restoring expression and enzymatic activity of glutathione peroxidase | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.9 | Homo sapiens | - |
- |
- |
| 1.11.1.12 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.11.1.9 | EAhy 926 cell | human endothelial cell line Ea.hy926 | Homo sapiens | - |
| 1.11.1.12 | endothelial cell line | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.9 | tert-butyl hydroperoxide + 2 GSH | - |
Homo sapiens | tert-butyl alcohol + GSSG + H2O | - |
? | |
| 1.11.1.12 | glutathione + tert-butylhydroperoxide | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.9 | cGPx | - |
Homo sapiens |
| 1.11.1.12 | GPX | - |
Homo sapiens |
| 1.11.1.12 | phospholipid hydroperoxide glutathione peroxidase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | glutathione | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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