Literature summary extracted from

Djordjevic, T.; Pogrebniak, A.; BelAiba, R.S.; Bonello, S.; Wotzlaw, C.; Acker, H.; Hess, J.; Goerlach, A.
The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells (2005), Free Radic. Biol. Med., 38, 616-630.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.6.3.1	thrombin	administration of thrombin to endothelial cells leads to upregulation of enzyme subunit p22phox accompanied by a delayed increase in generation of reactive oxygen species and enhanced proliferation. Existence of a positive feedback mechanism, whereby reactive oxygen species lead to elevated levels of p22phox and thus, sustained generation of reactive oxygen species as is observed in endothelial dysfunction	Homo sapiens

Application

EC Number	Application	Comment	Organism
1.6.3.1	medicine	administration of thrombin to endothelial cells leads to upregulation of enzyme subunit p22phox accompanied by a delayed increase in generation of reactive oxygen species and enhanced proliferation. Existence of a positive feedback mechanism, whereby reactive oxygen species lead to elevated levels of p22phox and thus, sustained generation of reactive oxygen species as is observed in endothelial dysfunction	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.3.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.6.3.1	EAhy 926 cell	endothelial hybridoma cell line	Homo sapiens	-

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Release 2023.1 (January 2023)