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Literature summary extracted from

  • Wangensteen, H.; Miron, A.; Alamgir, M.; Rajia, S.; Samuelsen, A.B.; Malterud, K.E.
    Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus (2006), Fitoterapia, 77, 290-295.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 11-hydroxytephrosin IC50: 0.071 mM Sarcolobus globosus
1.13.11.33 12alpha-hydroxydeguelin IC50: 0.018 mM Sarcolobus globosus
1.13.11.33 12alpha-hydroxyrotenone IC50: 0.102 mM Sarcolobus globosus
1.13.11.33 6,7-dimethoxy-2,3-dihydrochromone IC50: 0.137 mM Sarcolobus globosus
1.13.11.33 6-oxo-6alpha,12alpha-dehydrodeguelin
-
 Sarcolobus globosus
1.13.11.33 6alpha,12alpha-12alpha-hydroxyelliptone IC50: 0.062 mM Sarcolobus globosus
1.13.11.33 6alpha,12alpha-dehydrodeguelin IC50: 0.071 mM Sarcolobus globosus
1.13.11.33 barbigerone IC50: 0.063 mM Sarcolobus globosus
1.13.11.33 genistein IC50: above 0.167 mM Sarcolobus globosus
1.13.11.33 genistin IC50: above 0.167 mM Sarcolobus globosus
1.13.11.33 glucosyringic acid IC50: above 0.167 mM Sarcolobus globosus
1.13.11.33 isotachioside IC50: above 0.167 mM Sarcolobus globosus
1.13.11.33 quercetin IC50: 0.029 mM Sarcolobus globosus
1.13.11.33 sarcolobin IC50: 0.06 mM Sarcolobus globosus
1.13.11.33 tachioside IC50: above 0.167 mM Sarcolobus globosus
1.13.11.33 tephrosin IC50: 0.064 mM Sarcolobus globosus
1.13.11.33 vanillic acid 4-O-beta-D-glucoside IC50: 0.161 mM Sarcolobus globosus
1.13.11.33 villosinol
-
 Sarcolobus globosus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Sarcolobus globosus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Sarcolobus globosus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase
-
 Sarcolobus globosus
1.13.11.33 15-LO
-
 Sarcolobus globosus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.33 0.018
-
 IC50: 0.018 mM Sarcolobus globosus 12alpha-hydroxydeguelin
1.13.11.33 0.029
-
 IC50: 0.029 mM Sarcolobus globosus quercetin
1.13.11.33 0.06
-
 IC50: 0.06 mM Sarcolobus globosus sarcolobin
1.13.11.33 0.062
-
 IC50: 0.062 mM Sarcolobus globosus 6alpha,12alpha-12alpha-hydroxyelliptone
1.13.11.33 0.063
-
 IC50: 0.063 mM Sarcolobus globosus barbigerone
1.13.11.33 0.064
-
 IC50: 0.064 mM Sarcolobus globosus tephrosin
1.13.11.33 0.071
-
 IC50: 0.071 mM Sarcolobus globosus 11-hydroxytephrosin
1.13.11.33 0.071
-
 IC50: 0.071 mM Sarcolobus globosus 6alpha,12alpha-dehydrodeguelin
1.13.11.33 0.102
-
 IC50: 0.102 mM Sarcolobus globosus 12alpha-hydroxyrotenone
1.13.11.33 0.137
-
 IC50: 0.137 mM Sarcolobus globosus 6,7-dimethoxy-2,3-dihydrochromone
1.13.11.33 0.161
-
 IC50: 0.161 mM Sarcolobus globosus vanillic acid 4-O-beta-D-glucoside
1.13.11.33 0.167
-
 IC50: above 0.167 mM Sarcolobus globosus genistein
1.13.11.33 0.167
-
 IC50: above 0.167 mM Sarcolobus globosus genistin
1.13.11.33 0.167
-
 IC50: above 0.167 mM Sarcolobus globosus glucosyringic acid
1.13.11.33 0.167
-
 IC50: above 0.167 mM Sarcolobus globosus tachioside
1.13.11.33 0.167
-
 IC50: above 0.167 mM Sarcolobus globosus isotachioside