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Literature summary extracted from

  • Goerg, B.; Qvartskhava, N.; Voss, P.; Grune, T.; Haeussinger, D.; Schliess, F.
    Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration (2007), FEBS Lett., 581, 84-90.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.1.2 epicatechin 0.03 mM completely prevents inactivation of glutamine synthetase by peroxynitrite Rattus norvegicus
6.3.1.2 epicatechin 0.03 mM completely prevents inactivation of glutamine synthetase by peroxynitrite Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.2 peroxynitrite 0.005 mM, activity is decreased by about 25% Ovis aries
6.3.1.2 peroxynitrite 0.005 mM, inactivation of the enzyme Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Ovis aries
-
-
-
6.3.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.1.2 brain
-
Ovis aries
-
6.3.1.2 brain cortex
-
Rattus norvegicus
-
6.3.1.2 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.2 ATP + L-Glu + NH4+
-
Rattus norvegicus ADP + phosphate + L-Gln
-
?
6.3.1.2 ATP + L-Glu + NH4+
-
Ovis aries ADP + phosphate + L-Gln
-
?

Synonyms

EC Number Synonyms Comment Organism
6.3.1.2 Glutamine synthetase
-
Rattus norvegicus
6.3.1.2 Glutamine synthetase
-
Ovis aries