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Literature summary extracted from

  • Mitra, P.; Maceyka, M.; Payne, S.G.; Lamour, N.; Milstien, S.; Chalfant, C.E.; Spiegel, S.
    Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells (2007), FEBS Lett., 581, 735-740.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.138 siRNA downregulation of CerK with siRNA targeted against Cerk reduced cellular proliferation within 48 hours Homo sapiens
2.7.1.138 siRNA downregulation of CerK with siRNA targeted against Cerk reduced cellular proliferation within 48 hours Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.138 62000
-
 SDS-PAGE Mus musculus
2.7.1.138 62000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Mus musculus
-
 ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP Homo sapiens
-
 ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens
-
-
-
2.7.1.138 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 A-549 cell
-
 Homo sapiens
-
2.7.1.138 A-549 cell human lung adenocarcinoma cell Homo sapiens
-
2.7.1.138 fibroblast
-
 Homo sapiens
-
2.7.1.138 lung adenocarcinoma cell
-
 Homo sapiens
-
2.7.1.138 NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?
2.7.1.138 ceramide + ATP
-
 Mus musculus ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP
-
 Homo sapiens ceramide 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Mus musculus
2.7.1.138 CERK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.138 ATP
-
 Homo sapiens