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Literature summary extracted from

  • Xu, D.; Kishi, H.; Kawamichi, H.; Kajiya, K.; Takada, Y.; Kobayashi, S.
    Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts (2007), FEBS Lett., 581, 5227-5233.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 lysophosphatidic acid activates fyn Homo sapiens
2.7.10.2 sphingosylphosphorylcholine activates fyn Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.2 expression of wild-type Fyn and mutant enzymes in murine NIH3T3 fibroblasts Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 K298M site-directed mutagenesis, a dominant-negative enzyme mutant Homo sapiens
2.7.10.2 additional information overexpression of constitutively active Fyn Y530F mutant localized at both ends of F-actin bundles triggers stress fiber formation, gene silencing of Fyn by siRNA expression or expression of dominant negative Fyn mutant K298M inhibit actin stress fiber formation in fibroblasts Homo sapiens
2.7.10.2 Y530F site-directed mutagenesis, a constitutively active mutant Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 actin filament Fyn is localized at both ends of F-actin bundles Homo sapiens 5884
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 additional information Homo sapiens Fyn tyrosine kinase is involved in actin stress fiber formation in fibroblasts ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 additional information Fyn tyrosine kinase is involved in actin stress fiber formation in fibroblasts Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Fyn tyrosine kinase
-
 Homo sapiens