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Literature summary extracted from

  • Reinke, S.O.; Hinderlich, S.
    Prediction of three different isoforms of the human UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (2007), FEBS Lett., 581, 3327-3331.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.14 additional information Homo sapiens biosynthesis of sialic acids ?
-
?
5.1.3.14 additional information Mus musculus biosynthesis of sialic acids ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.60 Homo sapiens Q9Y223
-
-
2.7.1.60 Homo sapiens Q9Y223 isoform 2; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, isoform GNE2
-
2.7.1.60 Homo sapiens Q9Y223 isoform 3; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, isoform GNE3
-
5.1.3.14 Homo sapiens Q9Y223 isoform 2
-
5.1.3.14 Homo sapiens Q9Y223 isoform 3
-
5.1.3.14 Mus musculus Q3UW64
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.60 brain
-
Homo sapiens
-
2.7.1.60 colon
-
Homo sapiens
-
2.7.1.60 kidney
-
Homo sapiens
-
2.7.1.60 liver
-
Homo sapiens
-
2.7.1.60 lung
-
Homo sapiens
-
2.7.1.60 pancreas
-
Homo sapiens
-
2.7.1.60 placenta
-
Homo sapiens
-
5.1.3.14 brain
-
Homo sapiens
-
5.1.3.14 brain
-
Mus musculus
-
5.1.3.14 colon
-
Homo sapiens
-
5.1.3.14 colon
-
Mus musculus
-
5.1.3.14 kidney
-
Homo sapiens
-
5.1.3.14 kidney
-
Mus musculus
-
5.1.3.14 liver
-
Homo sapiens
-
5.1.3.14 liver
-
Mus musculus
-
5.1.3.14 lung
-
Homo sapiens
-
5.1.3.14 pancreas
-
Homo sapiens
-
5.1.3.14 placenta
-
Homo sapiens
-
5.1.3.14 skeletal muscle
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.60 ATP + N-acetyl-D-mannosamine
-
Homo sapiens ADP + N-acetyl-D-mannosamine 6-phosphate
-
?
2.7.1.60 additional information isoform GNE2 displays an extended N-terminus compared with isoform GNE, which is linked directly to the epimerase domain. Recombinant GNE2 still possesses both enzymatic activities of GNE Homo sapiens ?
-
?
2.7.1.60 additional information isoform GNE3 displays an deleted N-terminus compared with isoform GNE. Recombinant GNE3 shows a total loss of the epimerase activity Homo sapiens ?
-
?
5.1.3.14 additional information biosynthesis of sialic acids Homo sapiens ?
-
?
5.1.3.14 additional information biosynthesis of sialic acids Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.60 GNE2 enzyme isoform possessing extended N-terminus Homo sapiens
2.7.1.60 GNE3 enzyme isoform possessing deleted N-terminus Homo sapiens
2.7.1.60 UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
-
Homo sapiens
5.1.3.14 GNE1
-
Homo sapiens
5.1.3.14 GNE1
-
Mus musculus
5.1.3.14 GNE2
-
Homo sapiens
5.1.3.14 UDP-GlcNAc 2-epimerase
-
Homo sapiens
5.1.3.14 UDP-GlcNAc 2-epimerase
-
Mus musculus
5.1.3.14 UDP-N-acetylglucosamine 2-epimerase
-
Homo sapiens
5.1.3.14 UDP-N-acetylglucosamine 2-epimerase
-
Mus musculus