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Literature summary extracted from
- Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica (2006), FEBS Lett., 580, 5016-5022.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.11.1.24 | - |
Fasciola hepatica |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.11.1.24 | 0.0127 | - |
cumene hydroperoxide | 22°C, pH 7.0 | Fasciola hepatica |  |
| 1.11.1.24 | 0.0186 | - |
tert-butyl hydroperoxide | 22°C, pH 7.0 | Fasciola hepatica | |
| 1.11.1.24 | 0.03 | - |
H2O2 | 22°C, pH 7.0 | Fasciola hepatica | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.24 | Fasciola hepatica | P91883 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.11.1.24 | recombinant enzyme | Fasciola hepatica |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.11.1.24 | 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH | the enzyme exhibits a saturable, single-displacement-like reaction mechanism rather than non-saturable double displacement (ping-pong) enzyme substitution mechanism | Fasciola hepatica |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.24 | cumene hydroperoxide + reduced thioredoxin | - |
Fasciola hepatica | ? | - |
? | |
| 1.11.1.24 | H2O2 + reduced thioredoxin | - |
Fasciola hepatica | H2O + oxidized thioredoxin | - |
? | |
| 1.11.1.24 | tert-butyl hydroperoxide + reduced thioredoxin | - |
Fasciola hepatica | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.24 | 2-Cys peroxiredoxin | - |
Fasciola hepatica |
| 1.11.1.24 | FhePrx | - |
Fasciola hepatica |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.11.1.24 | 6.3 | - |
cumene hydroperoxide | 22°C, pH 7.0 | Fasciola hepatica | |
| 1.11.1.24 | 7.6 | - |
tert-butyl hydroperoxide | 22°C, pH 7.0 | Fasciola hepatica | |
| 1.11.1.24 | 15.8 | - |
H2O2 | 22°C, pH 7.0 | Fasciola hepatica | |
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