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Literature summary extracted from

  • Riley, A.M.; Deleu, S.; Qian, X.; Mitchell, J.; Chung, S.; Adelt, S.; Vogel, G.; Potter, B.V.; Shears, S.B.
    On the contribution of stereochemistry to human ITPK1 specificity: Ins(1,4,5,6)P4 is not a physiologic substrate (2006), FEBS Lett., 580, 324-330.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.151 inositol(1,3,4)-trisphosphate potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM Homo sapiens
2.7.1.151 inositol(3,5,6)-trisphosphate IC50: 0.1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.151 0.00018
-
 inositol (1,4,5,6)-tetrakisphosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.151 additional information Homo sapiens inositol (1,4,5,6)-tetrakisphosphate is not a physiological substrate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.151 Homo sapiens
-
 recombinant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.151 inositol (1,4,5,6)-tetrakisphosphate + ATP hITPK1 has more than 13000fold preference for inositol (3,4,5,6)-tetrakisphosphate over its enantiomer inositol (1,4,5,6)-tetrakisphosphate Homo sapiens inositol (1,3,4,5,6)-pentakisphosphate + ADP
-
 ?
2.7.1.151 inositol (3,4,5,6)-tetrakisphosphate + ATP hITPK1 has more than 13000fold preference for inositol (3,4,5,6)-tetrakisphosphate over its enantiomer inositol (1,4,5,6)-tetrakisphosphate Homo sapiens inositol (1,3,4,5,6)-pentakisphosphate + ADP
-
 ?
2.7.1.151 additional information inositol (1,4,5,6)-tetrakisphosphate is not a physiological substrate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.151 ITPK1
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.151 0.00015
-
 inositol (1,3,4)-trisphosphate
-
 Homo sapiens
2.7.1.151 0.002
-
 inositol (3,5,6)-trisphosphate
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.151 0.0076
-
 potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM Homo sapiens inositol(1,3,4)-trisphosphate
2.7.1.151 0.1
-
 IC50: 0.1 mM Homo sapiens inositol(3,5,6)-trisphosphate