Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sivaraman, S.; Kirsch, J.F.
    The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II (2006), FEBS J., 273, 1920-1929.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.5 expressed in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.6.1.5 I249A reduced catalytic activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.5 67
-
 L-tyrosine mutant enzyme I249A Homo sapiens
2.6.1.5 580
-
 p-hydroxyphenylpyruvate wild type enzyme Homo sapiens
2.6.1.5 870
-
 L-tyrosine wild type enzyme Homo sapiens
2.6.1.5 3300
-
 2-oxoglutarate wild type enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.5 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.5 NTA-resin column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.5 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.5 L-glutamate + 4-hydroxyphenylpyruvate
-
 Homo sapiens 2-oxoglutarate + L-tyrosine
-
 ?
2.6.1.5 L-tyrosine + 2-oxoglutarate
-
 Homo sapiens 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
2.6.1.5 additional information no detectable transamination of aspartate or other cosubstrates Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.5 TATase
-
 Homo sapiens
2.6.1.5 tyrosine aminotransferase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.5 0.25
-
 2-oxoglutarate wild type enzyme Homo sapiens
2.6.1.5 0.3
-
 2-oxoglutarate mutant enzyme I249A Homo sapiens
2.6.1.5 1
-
 L-tyrosine wild type enzyme Homo sapiens
2.6.1.5 1.2
-
 p-hydroxyphenylpyruvate wild type enzyme Homo sapiens
2.6.1.5 1.2
-
 L-tyrosine mutant enzyme I249A Homo sapiens
2.6.1.5 3.8
-
 L-glutamate wild type enzyme Homo sapiens
2.6.1.5 69
-
 L-glutamate wild type enzyme Homo sapiens
2.6.1.5 83
-
 L-tyrosine wild type enzyme Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.5 pyridoxal 5'-phosphate dependent Homo sapiens