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Literature summary extracted from

  • Ondarza, R.N.; Iturbe, A.; Hernandez, E.
    The effects by neuroleptics, antimycotics and antibiotics on disulfide reducing enzymes from the human pathogens Acanthamoeba polyphaga and Naegleria fowleri (2007), Exp. Parasitol., 115, 41-47.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.6 amphotericin 29% enhancement of activity at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 Mepacrine 56% enhancement of activity at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 metronidazole 4fold stimulation at a concentration of 0.032 mg/ml Naegleria fowleri
1.8.1.6 rifampicin 147% enhancement of activity at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.12 ketoconazole 18% enhancement of activity Naegleria fowleri
1.8.1.12 metronidazole 68% enhancement of activity Naegleria fowleri
1.8.1.12 Pentamidine 40% enhancement of activity Naegleria fowleri
1.8.1.12 rifampicin 55% enhancement of activity Naegleria fowleri

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.6 amphotericin 100% inhibition at a concentration of 0.032 mg/ml Naegleria fowleri
1.8.1.6 chlorpromazine 100% inhibition at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 chlorpromazine 100% inhibition at a concentration of 0.032 mg/ml Naegleria fowleri
1.8.1.6 ketoconazole 100% inhibition at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 Mepacrine 100% inhibition at a concentration of 0.032 mg/ml Naegleria fowleri
1.8.1.6 metronidazole 26% inhibition at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 miconazole 100% inhibition at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 miconazole 100% inhibition at a concentration of 0.032 mg/ml Naegleria fowleri
1.8.1.6 Pentamidine 58% inhibition at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 trifluoroperazine 100% inhibition at a concentration of 0.032 mg/ml Acanthamoeba polyphaga
1.8.1.6 trifluoroperazine 100% inhibition at a concentration of 0.032 mg/ml Naegleria fowleri
1.8.1.12 Amphotericin B 0.0346 mM, 100% inhibition Naegleria fowleri
1.8.1.12 chlorpromazine 0.0896 mM, 80% inhibition Naegleria fowleri
1.8.1.12 Mepacrine 0.0672 mM, 70% inhibition Naegleria fowleri
1.8.1.12 miconazole 0.064 mM, 100% inhibition Naegleria fowleri
1.8.1.12 Trifluoperazine 0.0655 mM, 92% inhibition Naegleria fowleri

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.6 Acanthamoeba polyphaga
-
-
-
1.8.1.6 Naegleria fowleri
-
-
-
1.8.1.12 Naegleria fowleri
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.6 NADH + L-cystine + H+
-
 Naegleria fowleri NAD+ + L-cysteine
-
 ?
1.8.1.6 NADH + L-cystine + H+
-
 Acanthamoeba polyphaga NAD+ + L-cysteine
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Naegleria fowleri trypanothione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.6 CysR
-
 Naegleria fowleri
1.8.1.6 CysR
-
 Acanthamoeba polyphaga
1.8.1.12 TR
-
 Naegleria fowleri
1.8.1.12 trypanothione reductase
-
 Naegleria fowleri

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 NADPH
-
 Naegleria fowleri