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Literature summary extracted from

  • Bizzoco, E.; Vannucchi, M.G.; Faussone-Pellegrini, M.S.
    Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons (2007), Exp. Neurol., 204, 252-259.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.3.2.1 medicine transient ischemia induces changes in the number and percentage of the nNOS+ neurons also expressing argininosuccinate lyase Rattus norvegicus
6.3.4.5 medicine transient ischemia induces changes in nitric oxide synthase, argininosuccinate synthetase and argininsuccinate lyase co-expression in the rat striatal neurons. At 24 h after reperfusion in the animals with a longer survival and better motor-sensory performances there is an increase in these neuronal populations. It is hypothesized that the elevated expression of argininosuccinate synthetase and argininsuccinate lyase protects ischemic striatal neurons from tissue damages by maintaining a correct NO production Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.2.1 2-(Nomega-L-arginino)succinate Rattus norvegicus
-
 fumarate + L-arginine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.1 Rattus norvegicus
-
 male wistar rat
-
6.3.4.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.1 brain striatal neurons Rattus norvegicus
-
6.3.4.5 corpus striatum in a rat ischemia model the striatum is examined at 24, 72 and 144 h after reperfusion and compared with rats in normal conditions. At 24 h after reperfusion, the number of the nitric oxide synthase-positive neurons and the percentage of those co-expressing argininosuccinate synthetase and argininsuccinate lyase and nitric oxide synthase are significantly increased in the animals with a longer survival Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.1 2-(Nomega-L-arginino)succinate
-
 Rattus norvegicus fumarate + L-arginine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.2.1 Argininosuccinate lyase
-
 Rattus norvegicus
4.3.2.1 ASL
-
 Rattus norvegicus
6.3.4.5 Argininosuccinate synthetase
-
 Rattus norvegicus
6.3.4.5 ASS
-
 Rattus norvegicus